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Isoescin IB

Name: Isoescin IB
Brand: TargetMol
SKU: TN1777
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1777Cas No. 219944-46-4

Isoescin IB is a natural product from Aesculus hippocastanum L. Isoescin IB and Escin IB are the chief active ingredients in escin.

Isoescin IB

🥰Excellent

Purity: 99.76%

Catalog No. TN1777Cas No. 219944-46-4

Isoescin IB is a natural product from Aesculus hippocastanum L. Isoescin IB and Escin IB are the chief active ingredients in escin.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$225	In Stock	In Stock
10 mg	$333	In Stock	In Stock
25 mg	$558	In Stock	In Stock
50 mg	$796	In Stock	In Stock
100 mg	$1,080	-	In Stock
1 mL x 10 mM (in DMSO)	$396	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

Isoescin IB is a natural product from Aesculus hippocastanum L. Isoescin IB and Escin IB are the chief active ingredients in escin.

In vivo

Five groups of Wistar rats (n=6 per group) were treated with either an intravenous (IV) dose (2.78mg/kg) of sodium escinate (corresponding to 0.5mg/kg of Escin IB and 0.5mg/kg of Isoescin IB), an IV dose (0.5mg/kg) and an oral dose (4mg/kg) of pure Escin IB or Isoescin IB. The administration of sodium escinate, which contains the two isomers, gave rise to higher terminal phase half-life (t1/2) and mean residence time (MRT) values for both Escin IB and Isoescin IB compared to the corresponding compounds administered alone. The absorption of Escin IB and Isoescin IB was very poor, with the oral bioavailability (F) values of <2% observed for both compounds. The two compounds were found to isomerize in vivo, wherein the conversion of Escin IB to Isoescin IB was much easier than that of Isoescin IB to Escin IB[1].

Chemical Properties

Molecular Weight	1131.26
Formula	C₅₅H₈₆O₂₄
Cas No.	219944-46-4
Smiles	[H][C@@]1(O[C@H]2[C@H](O)[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@]([H])(O[C@H]3CC[C@@]4(C)[C@@]([H])(CC[C@]5(C)[C@]4([H])CC=C4[C@]6([H])CC(C)(C)[C@@H](OC(=O)C(\C)=C/C)[C@H](O)[C@]6(COC(C)=O)[C@H](O)C[C@@]54C)[C@@]3(C)CO)O[C@@H]2C(O)=O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.46 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (88.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (3.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8840 mL	4.4199 mL	8.8397 mL	44.1985 mL
5 mM	0.1768 mL	0.8840 mL	1.7679 mL	8.8397 mL
10 mM	0.0884 mL	0.4420 mL	0.8840 mL	4.4199 mL
20 mM	0.0442 mL	0.2210 mL	0.4420 mL	2.2099 mL
50 mM	0.0177 mL	0.0884 mL	0.1768 mL	0.8840 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc