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Acridone

Name: Acridone
Brand: TargetMol
SKU: T20003
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20003Cas No. 578-95-0

Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.

Acridone

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Purity: 99.84%

Catalog No. T20003Cas No. 578-95-0

Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:Yellow to Green

Resource Download

COA HPLC HNMR

Product Introduction

Acridone AI Summary

Acridone exhibits a wide range of bioactivities and moderate lipophilicity, with a logP value of 2.975. This compound demonstrates moderate fluorescence quenching of ethidium bound to [(poly dG-dC)]2 DNA and moderate cytotoxic potency against CH1 cells (IC50 of 77000.0 nM). In various other cell lines, its cytotoxic potency has IC50 values greater than 100000.0 nM. It shows antiproliferative activity against human CCRF-CEM and HaCaT cells, both with IC50 values greater than 100000.0 nM and 50000.0 nM, respectively. Acridone is involved in inhibiting and activating multiple proteins and pathways, including Lamin A splicing, Jumonji Domain Containing 2E, and Human alpha-Glucosidase. This compound also reveals cytotoxic effects in DNA re-replication assays for normal breast cells and colon adenocarcinoma cells, and displays inhibition against Hepatitis C Virus (HCV) and ATXN expression assays. Additionally, it demonstrates significant activity against luciferase/luciferin-expressing antifolate-resistant parasites infecting HepG2 cells with IC50 values of 1.57 uM and CC50 value of 1.57 uM. Acridone binds to heme (Ka of 2.4 x 10^4/M) and inhibits heme-mediated bovine serum albumin oxidation (IC50 of 55000.0 nM), indicating its potential multi-target bioactivity profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.

Chemical Properties

Molecular Weight	195.22
Formula	C₁₃H₉NO
Cas No.	578-95-0
Smiles	O=c1c2ccccc2[nH]c2ccccc12
Relative Density.	1.23 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (332.96 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (12.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1224 mL	25.6121 mL	51.2243 mL	256.1213 mL
5 mM	1.0245 mL	5.1224 mL	10.2449 mL	51.2243 mL
10 mM	0.5122 mL	2.5612 mL	5.1224 mL	25.6121 mL
20 mM	0.2561 mL	1.2806 mL	2.5612 mL	12.8061 mL
50 mM	0.1024 mL	0.5122 mL	1.0245 mL	5.1224 mL
100 mM	0.0512 mL	0.2561 mL	0.5122 mL	2.5612 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc