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Fortunellin

🥰Excellent
Catalog No. TN4077Cas No. 20633-93-6

Fortunellin is a flavonoid isolated from Fortunella margarita (kumquat) that alleviates histopathological heart injury while improving cardiac function by reducing inflammation and oxidative stress in fructose-induced metabolic disease models. Fortunellin decreases pro-inflammatory cytokines and suppresses phosphorylation of IKKα, IκBα, and NF-κB, while upregulating antioxidant defenses including SOD, CAT, HO-1, and activating AMPK/Nrf2 signaling, supporting the use of Fortunellin in research on diabetic cardiomyopathy and cardiometabolic disorders.

Fortunellin

Fortunellin

🥰Excellent
Purity: 98.38%
Catalog No. TN4077Cas No. 20633-93-6
Fortunellin is a flavonoid isolated from Fortunella margarita (kumquat) that alleviates histopathological heart injury while improving cardiac function by reducing inflammation and oxidative stress in fructose-induced metabolic disease models. Fortunellin decreases pro-inflammatory cytokines and suppresses phosphorylation of IKKα, IκBα, and NF-κB, while upregulating antioxidant defenses including SOD, CAT, HO-1, and activating AMPK/Nrf2 signaling, supporting the use of Fortunellin in research on diabetic cardiomyopathy and cardiometabolic disorders.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$44-In Stock
2 mg$62-In Stock
5 mg$98-In Stock
10 mg$163-In Stock
25 mgPreferential-In Stock
50 mgPreferential-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.38%
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Product Introduction

Bioactivity
Description
Fortunellin is a flavonoid isolated from Fortunella margarita (kumquat) that alleviates histopathological heart injury while improving cardiac function by reducing inflammation and oxidative stress in fructose-induced metabolic disease models. Fortunellin decreases pro-inflammatory cytokines and suppresses phosphorylation of IKKα, IκBα, and NF-κB, while upregulating antioxidant defenses including SOD, CAT, HO-1, and activating AMPK/Nrf2 signaling, supporting the use of Fortunellin in research on diabetic cardiomyopathy and cardiometabolic disorders.
In vitro
Fortunellin induces the Nrf2 signaling pathway by promoting AMPK phosphorylation, thereby significantly reducing oxidative stress levels through upregulation of the antioxidant factors SOD, CAT, and HO-1 [2].
Chemical Properties
Molecular Weight592.55
FormulaC28H32O14
Cas No.20633-93-6
SmilesO=C1C=2C(OC(=C1)C3=CC=C(OC)C=C3)=CC(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)=CC2O
Relative Density.1.62g/cm3
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (135.01 mM), Sonication is recommeded.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6876 mL8.4381 mL16.8762 mL84.3811 mL
5 mM0.3375 mL1.6876 mL3.3752 mL16.8762 mL
10 mM0.1688 mL0.8438 mL1.6876 mL8.4381 mL
20 mM0.0844 mL0.4219 mL0.8438 mL4.2191 mL
50 mM0.0338 mL0.1688 mL0.3375 mL1.6876 mL
100 mM0.0169 mL0.0844 mL0.1688 mL0.8438 mL

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Keywords

Fortunellin
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