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Boc-Asp(OMe)-fluoromethyl ketone

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Catalog No. T39308Cas No. 187389-53-3
Alias Boc-Asp(OMe)-FMK, Boc-Asp(OMe)-fluoromethyl ketone

Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.

Boc-Asp(OMe)-fluoromethyl ketone

Boc-Asp(OMe)-fluoromethyl ketone

🥰Excellent
Catalog No. T39308Alias Boc-Asp(OMe)-FMK, Boc-Asp(OMe)-fluoromethyl ketoneCas No. 187389-53-3
Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.
Pack SizePriceAvailabilityQuantity
1 mg$40In Stock
5 mg$97In Stock
10 mg$155In Stock
25 mg$313In Stock
50 mg$493In Stock
100 mg$723In Stock
1 mL x 10 mM (in DMSO)$94In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:≥98%
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COA HNMR

Product Introduction

Bioactivity
Description
Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.
In vitro
Boc-Asp(OME)-Fluoromethyl Keton (100 μM; 30 minutes; Polymorphonuclear leukocytes) prevents Fas-induced and spontaneous apoptosis (-CH-11)[1], and at 20 μM for 5 hours in J774.1/JA-4 cells, it significantly increases the release of LDH[2].
SynonymsBoc-Asp(OMe)-FMK, Boc-Asp(OMe)-fluoromethyl ketone
Chemical Properties
Molecular Weight263.26
FormulaC11H18FNO5
Cas No.187389-53-3
Smiles[C@H](NC(OC(C)(C)C)=O)(CC(OC)=O)C(CF)=O
Relative Density.1.150 g/cm3 at 20℃
ColorYellow
AppearanceSolid
SequenceBoc-Asp(OMe)-CH2F
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (227.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7985 mL18.9926 mL37.9853 mL189.9263 mL
5 mM0.7597 mL3.7985 mL7.5971 mL37.9853 mL
10 mM0.3799 mL1.8993 mL3.7985 mL18.9926 mL
20 mM0.1899 mL0.9496 mL1.8993 mL9.4963 mL
50 mM0.0760 mL0.3799 mL0.7597 mL3.7985 mL
100 mM0.0380 mL0.1899 mL0.3799 mL1.8993 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

spontaneousruptureoxidativeLDHInhibitorinhibitFas-inducedCaspasebroadBocAsp(OMe)fluoromethyl ketoneBoc Asp(OMe) fluoromethyl ketoneapoptosis
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