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Salermide

Name: Salermide
Brand: TargetMol
SKU: T3953
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3953Cas No. 1105698-15-4

Salermide, an inhibitor of Sirt1 and Sirt2, induces cancer-specific apoptotic cell death.

Salermide

🥰Excellent

Purity: 99.55%

Catalog No. T3953Cas No. 1105698-15-4

Salermide, an inhibitor of Sirt1 and Sirt2, induces cancer-specific apoptotic cell death.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$106	In Stock	In Stock
50 mg	$197	In Stock	In Stock
100 mg	$297	In Stock	-
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.55%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Salermide, an inhibitor of Sirt1 and Sirt2, induces cancer-specific apoptotic cell death.
In vitro	Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent[1].
In vivo	Salermide is well tolerated by mice at concentrations up to 100 μM, with no adverse health effects observed in terms of diet consumption, body-weight gain, or postural and behavioral changes [1].
Cell Research	Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay as described earlier. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100?μm) for 24?h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus.(Only for Reference)

Chemical Properties

Molecular Weight	394.47
Formula	C₂₆H₂₂N₂O₂
Cas No.	1105698-15-4
Smiles	CC(C(=O)Nc1cccc(c1)\N=C\c1c(O)ccc2ccccc12)c1ccccc1
Relative Density.	1.16 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (114.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.07 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5350 mL	12.6752 mL	25.3505 mL	126.7524 mL
5 mM	0.5070 mL	2.5350 mL	5.0701 mL	25.3505 mL
10 mM	0.2535 mL	1.2675 mL	2.5350 mL	12.6752 mL
20 mM	0.1268 mL	0.6338 mL	1.2675 mL	6.3376 mL
50 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5350 mL
100 mM	0.0254 mL	0.1268 mL	0.2535 mL	1.2675 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc