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Ampyrone

Name: Ampyrone
Brand: TargetMol
SKU: T0050
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0050Cas No. 83-07-8

Alias Solnapyrin-A, NSC 60242, Minoazophene, Aminoantipyrin, 4-Aminoantipyrine

Ampyrone (4-Aminoantipyrine) is a reagent for glucose determination in the presence of peroxidase and phenol.

Ampyrone

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Purity: 98.58%

Catalog No. T0050Alias Solnapyrin-A, NSC 60242, Minoazophene, Aminoantipyrin, 4-AminoantipyrineCas No. 83-07-8

Ampyrone (4-Aminoantipyrine) is a reagent for glucose determination in the presence of peroxidase and phenol.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$35	In Stock	In Stock
5 g	$81	-	In Stock
10 g	$118	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.58%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ampyrone (4-Aminoantipyrine) is a reagent for glucose determination in the presence of peroxidase and phenol.
In vitro	The level of glutathione(GSH) in single erythrocytes is impacted slightly at low AAP(4-aminoantipyrine) concentrations probably due to the protection of glutathione reductase. When AAP concentration further increases, AAP has a significant influence on GSH[2].
In vivo	4-aminoantipyrine (4-AA) is not genotoxic and mutagenic in vivo, it can interfere with DNA damaging agents biological activities and may reduce the effectiveness of DNA damage-based chemotherapy[3].
Cell Research	Erythrocytes in PBS are incubated for 2 h at ambient temperature (without mixing) with AAP in concentrations from 1 × 10−6 mol/L to 1 × 10−3 mol/L. Sample of erythrocytes without AAP is used as control. After the exposure of AAP, erythrocytes are washed with borate buffer (pH 9.0) 2 times by centrifuging and determined for GSH. (Only for Reference)
Synonyms	Solnapyrin-A, NSC 60242, Minoazophene, Aminoantipyrin, 4-Aminoantipyrine

Chemical Properties

Molecular Weight	203.24
Formula	C₁₁H₁₃N₃O
Cas No.	83-07-8
Smiles	CS(=O)(=O)N(CC(O)=O)C1=CC(F)=CC=C1
Relative Density.	0.8 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40 mg/mL (196.81 mM), Sonication is recommended.

H2O: 37 mg/mL (182.05 mM), Sonication is recommended.

DMSO: 74.29 mg/mL (365.53 mM)

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9203 mL	24.6015 mL	49.2029 mL	246.0146 mL
5 mM	0.9841 mL	4.9203 mL	9.8406 mL	49.2029 mL
10 mM	0.4920 mL	2.4601 mL	4.9203 mL	24.6015 mL
20 mM	0.2460 mL	1.2301 mL	2.4601 mL	12.3007 mL
50 mM	0.0984 mL	0.4920 mL	0.9841 mL	4.9203 mL
100 mM	0.0492 mL	0.2460 mL	0.4920 mL	2.4601 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc