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Methyl oleanonate
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Catalog No. TN7060Cas No. 1721-58-0
3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.
Methyl oleanonate
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Purity: 98.99%
Catalog No. TN7060Cas No. 1721-58-0
3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $81 | - | In Stock | |
| 5 mg | $213 | - | In Stock | |
| 10 mg | $322 | - | In Stock | |
| 25 mg | $538 | - | In Stock | |
| 50 mg | $768 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.99%
Appearance:Solid
Color:White
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Product Introduction
Methyl oleanonate AI Summary
Methyl oleanonate exhibits multifaceted bioactivity across various biological assays. It acts as an inhibitor of recombinant PTP1B, with a minimal inhibition of 1.56% at a concentration of 5 µg/mL after 30 minutes according to spectrophotometry. The compound demonstrates significant cytotoxic activity against multiple human cancer cell lines: it inhibits the growth of T47D, PC3, and SR cells by 75.65%, 85.25%, and 63.87% respectively at 10^-5 M after 48 hours. When tested against MCF7 cells, Methyl oleanonate shows an IC50 value of 78,700.0 nM, and for other cell lines (HT-29, PC3, MDA-MB-231, MDA-MB-453, HeLa, and ME180), the IC50 values exceed 100,000.0 nM. Additionally, it inhibits LPS-induced NO production in mouse RAW264.7 and J774A1 cells with IC50 values of 31,700.0 nM and 33,500.0 nM, respectively, and displays cytotoxicity with IC50 values of 79,300.0 nM and 82,470.0 nM in the same cells. Using an SRB assay after 96 hours, it shows cytotoxicity against human 518A2, HT-29, and MCF7 cells with EC50 values of 4,110.0 nM, 4,470.0 nM, and 5,440.0 nM, respectively. Lastly, Methyl oleanonate has weak bioactivity with no inhibitory effect on TNF-alpha stimulated NF-kappaB and IFN-gamma stimulated STAT3, but it displays weak activation of Nrf2 in human HaCaT cells..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties. |
| Molecular Weight | 468.71 |
| Formula | C31H48O3 |
| Cas No. | 1721-58-0 |
| Smiles | [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CCC(=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(=O)OC |
| Relative Density. | 1.06 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 2 mg/mL (4.27 mM), Sonication and heating to 60℃ are recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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