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Anti-ITGB4 Antibody (5T264)
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Catalog No. TMAH-00651
Anti-ITGB4 Antibody (5T264) is an antibody targeting ITGB4. Anti-ITGB4 Antibody (5T264) can be used in ELISA,FCM.
Anti-ITGB4 Antibody (5T264)
Anti-ITGB4 Antibody (5T264)
😃Good
Catalog No. TMAH-00651
Anti-ITGB4 Antibody (5T264) is an antibody targeting ITGB4. Anti-ITGB4 Antibody (5T264) can be used in ELISA,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-ITGB4 Antibody (5T264) is an antibody targeting ITGB4. Anti-ITGB4 Antibody (5T264) can be used in ELISA,FCM. |
| Ig Type | Mouse IgG2a |
| Clone | 5T264 |
| Reactivity | Human |
| Verified Activity | Overlay Peak curve showing A549 cells surface stained with TMAH-00651 (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed. |
| Application | |
| Recommended Dose | FCM:1:20-1:500. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes. |
| Tissue Specificity | Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human ITGB4 Protein |
| Antigen Species | Human |
| Gene Name | ITGB4 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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