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Zomepirac sodium salt

Name: Zomepirac sodium salt
Brand: TargetMol
SKU: T0264
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0264Cas No. 64092-48-4

Alias Zomepirac Sodium, McN-2783-21-98

Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.

Zomepirac sodium salt

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Purity: 99.01%

Catalog No. T0264Alias Zomepirac Sodium, McN-2783-21-98Cas No. 64092-48-4

Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$31	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.01%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Zomepirac sodium salt AI Summary

Zomepirac sodium salt exhibits a versatile range of bioactivities. It shows significant anti-inflammatory and analgesic activities, as evidenced by effective doses in the rat adjuvant-induced polyarthritis test and the acetylcholine-induced body constriction assay, respectively. It also inhibits collagen-induced platelet aggregation in vitro. However, caution is necessary due to its ulcerogenic activity in rats at certain doses. Additionally, Zomepirac sodium salt modulates Lamin A splicing, enhances SMN2 splice variant expression, and acts as an agonist for the Thyroid Stimulating Hormone Receptor. It inhibits Tyrosyl-DNA Phosphodiesterase, Aldehyde Dehydrogenase 1 (ALDH1A1), PPTase, and Human Flap endonuclease 1 (FEN1), while activating Peroxisome Proliferator-activated Receptors (PPARs) and retinoid X receptor alpha signaling. It also affects HP1-beta Chromodomain interactions with methylated histone tails and inhibits the vitamin D receptor (VDR). Notably, Zomepirac sodium salt inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells at a concentration of 10 μM. However, it displays low bioactivity against SARS-CoV-2 in Vero E6 cells with an inhibition index of 0.1068..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.
Synonyms	Zomepirac Sodium, McN-2783-21-98

Chemical Properties

Molecular Weight	313.71
Formula	C₁₅H₁₃ClNNaO₃
Cas No.	64092-48-4
Smiles	[Na+].Cn1c(CC(=O)[O-])cc(C)c1C(=O)c1ccc(Cl)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (318.77 mM), Sonication is recommended.

H2O: 5 mg/mL (15.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1877 mL	15.9383 mL	31.8766 mL	159.3829 mL
5 mM	0.6375 mL	3.1877 mL	6.3753 mL	31.8766 mL
10 mM	0.3188 mL	1.5938 mL	3.1877 mL	15.9383 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1594 mL	0.7969 mL	1.5938 mL	7.9691 mL
50 mM	0.0638 mL	0.3188 mL	0.6375 mL	3.1877 mL
100 mM	0.0319 mL	0.1594 mL	0.3188 mL	1.5938 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc