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Anti-Epac2 Polyclonal Antibody
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Catalog No. TMAB-05602
Anti-Epac2 Polyclonal Antibody is a Rabbit antibody targeting Epac2. Anti-Epac2 Polyclonal Antibody can be used in WB.
Anti-Epac2 Polyclonal Antibody
Anti-Epac2 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-05602
Anti-Epac2 Polyclonal Antibody is a Rabbit antibody targeting Epac2. Anti-Epac2 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Epac2 Polyclonal Antibody is a Rabbit antibody targeting Epac2. Anti-Epac2 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Sheep) |
| Verified Activity | 1. Sample: HL60 (Human) Cell Lysate at 30 μg Primary: Anti-Epac2 (TMAB-05602) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 116 kD Observed band size: 116 kD 2. Sample: Liver (Mouse) Lysate at 40 μg Primary: Anti-aEpac2 (TMAB-05602) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 116 kD Observed band size: 116 kD 3. Protein: liver (mouse) lysate at 40 μg; brain (mouse) lysate at 40 μg; Primary: rabbit Anti-Epac2 (TMAB-05602) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG at 1: 5000; Predicted band size: 116 kD Observed band size: 116 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Membrane. |
| Tissue Specificity | Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | 3',5' cyclic adenosine monophosphate (cAMP)-regulated guanine nucleotide exchange factors Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the ras family GTPases Rap1 and Rap2 by promoting GTP binding in a cAMP-dependent manner (1,2). Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission (3). Human EPAC2 contains at least 31 exons and maps to chromosome 2q31 (4). The 4.4-kb Epac2 transcript is prominent in brain and adrenal gland (5,6). Within the brain, expression is strong in cortex, occipital pole, frontal lobe, temporal lobe, amygdala, putamen, hippocampus and cerebellum (5,6). |
| Immunogen | KLH conjugated synthetic peptide: human Epac2 |
| Antigen Species | Human |
| Gene Name | RAPGEF4 |
| Gene ID | |
| Protein Name | Rap guanine nucleotide exchange factor 4 |
| Uniprot ID | |
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. |
| Molecular Weight | Theoretical: 116 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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