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VTP-27999 TFA

Name: VTP-27999 TFA
Brand: TargetMol
SKU: T7668
Rating: 4.5 (1 reviews)

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Catalog No. T7668Cas No. 1013937-63-7

VTP-27999 TFA is an inhibitor of Renin (IC50 : 0.47 nM).

VTP-27999 TFA

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Purity: 98.84%

Catalog No. T7668Cas No. 1013937-63-7

VTP-27999 TFA is an inhibitor of Renin (IC50 : 0.47 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	Inquiry	Inquiry
5 mg	$81	Inquiry	Inquiry
10 mg	$137	Inquiry	Inquiry
25 mg	$289	Inquiry	Inquiry
50 mg	$483	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.84%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	VTP-27999 TFA is an inhibitor of Renin (IC50 : 0.47 nM).
Targets&IC50	Renin:0.47 nM
In vitro	In vitro,VTP-27999 increased renin immunoreactivity for a given amount of renin by ≥ 30%[]1

Chemical Properties

Molecular Weight	639.1
Formula	C₂₈H₄₂ClF₃N₄O₇
Cas No.	1013937-63-7
Smiles	OC(=O)C(F)(F)F.CN[C@H](CNC(=O)N1CCC[C@H](C1)[C@@H](OCCNC(=O)OC)c1cccc(Cl)c1)C[C@H]1CCCOC1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (15.65 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.5647 mL	7.8235 mL	15.6470 mL	78.2350 mL
5 mM	0.3129 mL	1.5647 mL	3.1294 mL	15.6470 mL
10 mM	0.1565 mL	0.7824 mL	1.5647 mL	7.8235 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc