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Anti-FGFR4 Antibody (2D158)
😃Good
Catalog No. TMAY-00957
Alias TKF, JTK2, fibroblast growth factor receptor 4, CD334
Anti-FGFR4 Antibody (2D158) is a Mouse antibody targeting FGFR4. Anti-FGFR4 Antibody (2D158) can be used in ELISA,ELISA(Cap).
Anti-FGFR4 Antibody (2D158)
Anti-FGFR4 Antibody (2D158)
😃Good
Catalog No. TMAY-00957Alias TKF, JTK2, fibroblast growth factor receptor 4, CD334
Anti-FGFR4 Antibody (2D158) is a Mouse antibody targeting FGFR4. Anti-FGFR4 Antibody (2D158) can be used in ELISA,ELISA(Cap).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $68 | 7-10 days | |
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA, ELISA(Cap) Reactivity: Human |
| Alias | TKF, JTK2, fibroblast growth factor receptor 4, CD334 |
| Ig Type | Mouse IgG1 |
| Clone | 2D158 |
| Reactivity | Human |
| Application | ELISA,ELISA(Cap) |
| Recommended Dose | ELISA: 1:1000-1:2000; ELISA(Cap): 1:250-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FGFR4 / CD334 (rh FGFR4 / CD334; TMPY-02112; NP_002002.3; Met 1-Asp 369). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human FGFR4 / CD334 protein (TMPY-02112) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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