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ML348

Name: ML348
Brand: TargetMol
SKU: T3439
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3439Cas No. 899713-86-1

Alias GNF-Pf-1127

ML348 (GNF-Pf-1127) is a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) with an IC50 of 210 nM.

ML348

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Purity: 99.88%

Catalog No. T3439Alias GNF-Pf-1127Cas No. 899713-86-1

ML348 (GNF-Pf-1127) is a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) with an IC50 of 210 nM.

Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$63	In Stock
10 mg	$98	In Stock
25 mg	$239	In Stock
50 mg	$372	In Stock
100 mg	$597	In Stock
200 mg	$833	In Stock
500 mg	$1,260	In Stock

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Batch Information

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Purity:99.88%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	ML348 (GNF-Pf-1127) is a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) with an IC50 of 210 nM.
Targets&IC50	LYPLA1:210 nM
Synonyms	GNF-Pf-1127

Chemical Properties

Molecular Weight	415.79
Formula	C₁₈H₁₇ClF₃N₃O₃
Cas No.	899713-86-1
Smiles	FC(F)(F)c1ccc(Cl)c(NC(=O)CN2CCN(CC2)C(=O)c2ccco2)c1
Relative Density.	1.422 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (200.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4051 mL	12.0253 mL	24.0506 mL	120.2530 mL
5 mM	0.4810 mL	2.4051 mL	4.8101 mL	24.0506 mL
10 mM	0.2405 mL	1.2025 mL	2.4051 mL	12.0253 mL
20 mM	0.1203 mL	0.6013 mL	1.2025 mL	6.0127 mL
50 mM	0.0481 mL	0.2405 mL	0.4810 mL	2.4051 mL
100 mM	0.0241 mL	0.1203 mL	0.2405 mL	1.2025 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc