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ML348

Name: ML348
Brand: TargetMol
SKU: T3439
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3439Cas No. 899713-86-1

Alias GNF-Pf-1127

ML348 (GNF-Pf-1127) is a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) with an IC50 of 210 nM.

ML348

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Purity: 99.88%

Catalog No. T3439Alias GNF-Pf-1127Cas No. 899713-86-1

ML348 (GNF-Pf-1127) is a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) with an IC50 of 210 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$39	In Stock	In Stock
5 mg	$63	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$239	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$597	In Stock	In Stock
200 mg	$833	In Stock	In Stock
500 mg	$1,260	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML348 (GNF-Pf-1127) is a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) with an IC50 of 210 nM.
Targets&IC50	LYPLA1:210 nM
Synonyms	GNF-Pf-1127

Chemical Properties

Molecular Weight	415.79
Formula	C₁₈H₁₇ClF₃N₃O₃
Cas No.	899713-86-1
Smiles	FC(F)(F)c1ccc(Cl)c(NC(=O)CN2CCN(CC2)C(=O)c2ccco2)c1
Relative Density.	1.422 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (200.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4051 mL	12.0253 mL	24.0506 mL	120.2530 mL
5 mM	0.4810 mL	2.4051 mL	4.8101 mL	24.0506 mL
10 mM	0.2405 mL	1.2025 mL	2.4051 mL	12.0253 mL
20 mM	0.1203 mL	0.6013 mL	1.2025 mL	6.0127 mL
50 mM	0.0481 mL	0.2405 mL	0.4810 mL	2.4051 mL
100 mM	0.0241 mL	0.1203 mL	0.2405 mL	1.2025 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc