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TargetMol | Compound Library

Glutamine Metabolism Compound Library

Catalog No. L2550

L-glutamine is a non-essential amino acid that is often simply called glutamine. It is produced by the body. Glutamine is synthesized from NH4+ and glutamate. The conversion of glutamate to glutamine is regulated by glutamine synthetase (GS) and is a key step in nitrogen metabolism. Although normally synthesized in adequate amounts, endogenous glutamine production may be inadequate during periods of metabolic stress or under the condition of disease. Glutamine is crucial for many metabolic functions, including protein and glutathione synthesis, energy production, maintenance of optimal antioxidant status, and immune function. Glutamine is the main metabolic substrate of macrophages and important for the function of macrophages; Glutamine is an important biosynthetic precursor for amino acid, protein and nucleic acid synthesis; Glutamine serves as a source of fuel for the cells lining the intestines, and without it, these cells may waste away; Glutamine is significantly involved in the synthesis of glutathione, a very important intracellular antioxidant and detoxication factor. Cancer cells undergo a reprogramming of metabolism in order to maintain bioenergetics, redox status, cell signaling and biosynthesis, in what is often a poorly vascularized, nutrient-deprived microenvironment. A metabolic characteristic of many cancer cells is a dependence on an exogenous supply of glutamine, exhibiting "glutamine addiction". Glutamine enters the cell through the amino acid transporter, ASCT2/SLC1A5, and is converted to glutamate in the mitochondria through a deamination reaction catalyzed by glutaminase (GLS). Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), which produce their corresponding amino acid in addition to α-KG, a process termed glutaminolysis. Humans express 4 isoforms of glutaminase which is the restriction and initiation enzyme in the glutaminolytic pathway. GLS encodes 2 types of kidney-type glutaminase with a high activity and low Km. GLS2 encodes 2 forms of liver-type glutaminase with a low activity and allosteric regulation. Glutamine coordinates intracellular signaling to promote cancer growth in addition to acting as an important substrate for carbon and nitrogen production. For example, MYC transcriptionally represses miR-23a/b, leading to higher expression of mitochondrial glutaminase. Glutamine stimulates mTORC1 activity and in turn, impairs autophagy initiation through the negative regulation of ULK1 by several mechanisms. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment. TargetMol owns a unique collection of 941 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for research in glutamine metabolic processes and drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2550

Glutamine Metabolism Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 941 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and cancer;
  • Targets include glutaminase(GLS)、ASCT2、glutamate dehydrogenase、c-Myc, etc.
  • Some compounds have been approved by the FDA;
  • Structurally diverse, medicinally active, and cell permeable;
  • Detailed compound information with structure, target, IC50 value, and bioactivity information;
  • NMR and HPLC/LCMS validated to ensure high purity

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Apoptosis
Autophagy
GluR
mTOR
iGluR
Akt
AMPK
Endogenous Metabolite
HIF/HIF Prolyl-Hydroxylase
PI3K
Glucocorticoid Receptor
Sirtuin
Ras
HIF
NMDAR
ERK
Antibacterial
NF-κB
Raf
Dehydrogenase
MDM-2/p53
Reactive Oxygen Species
Ferroptosis
p53
SGLT
Glutathione Peroxidase
c-Myc
DNA-PK
S6 Kinase
COX
Antibiotic
Mitophagy
VEGFR
MEK
Parasite
Glutaminase
PPAR
HIV Protease
p38 MAPK
Caspase
Calcium Channel
Isocitrate Dehydrogenase (IDH)
transporter
Influenza Virus
STAT
TNF
Potassium Channel
HMG-CoA Reductase
Src
Estrogen/progestogen Receptor
NADPH
JNK
CDK
Cytochromes P450
PKC
E1/E2/E3 Enzyme
PKM
Mdm2
Virus Protease
Rho
PDGFR
Lipoxygenase
DNA/RNA Synthesis
AChR
Sodium Channel
Amino Acids and Derivatives
PKA
Mitochondrial Metabolism
Bcl-2 Family
Nrf2
ATM/ATR
FLT
c-Kit
Antifungal
Phosphatase
Wnt/beta-catenin
Adrenergic Receptor
ROS
IL Receptor
Epigenetic Reader Domain
SARS-CoV
GABA Receptor
FGFR
c-RET
Tyrosinase
Microtubule Associated
ADC Cytotoxin
Antioxidant
Histamine Receptor
GSK-3
Progesterone Receptor
PARP
ROCK
Aryl Hydrocarbon Receptor
Annexin A
MMP
Aurora Kinase
Interleukin
LRRK2
GST
HDAC
PDK
NADPH-oxidase
Kras
NOS
HCV Protease
Tie-2
TRP/TRPV Channel
GlyT
HSV
CXCR
Cholinesterase (ChE)
Androgen Receptor
EGFR
ATP Citrate Lyase
MAPK
HSP
Pyroptosis
FKBP
GPX
Cannabinoid Receptor
Anti-infection
NO Synthase
ATPase
Chloride channel
Carbonic Anhydrase
Histone Methyltransferase
Integrin
c-Met/HGFR
DNA Alkylator/Crosslinker
PERK
GTPase
CaSR
HBV
ASCT
Serine Protease
FXR
Topoisomerase
Myosin
Bcr-Abl
Gamma-secretase
Glucagon Receptor
Fatty Acid Synthase
JAK
PTEN
IGF-1R
CaMK
TGF-beta/Smad
OXPHOS
Glutathione reductase
P-gp
Antiviral
Decarboxylase
Casein Kinase
IκB/IKK
Beta Amyloid
Reverse Transcriptase
c-Fms
Phospholipase
5-HT Receptor
Hydroxylase
Complement System
FAK
ROS Kinase
PD-1/PD-L1
PGK1
GPCR
Proton pump
NPC1L1
Dopamine Receptor
ROR
Y Box Binding Protein 1
YAP
Arginase
Adenosine Receptor
BACE
IFNAR
Histone Demethylase
RAAS
Melatonin Receptor
MRP
Estrogen Receptor/ERR
Liver X Receptor
Glucokinase
PYK2
NR4A
Amylase
MAO
IDO
Prolyl Endopeptidase (PREP)
SIK
UGT
LDL
Drug Metabolite
MT Receptor
Glucosidase
Monoamine Transporter
Guanylate cyclase
Smo
PAK
ACK1
Angiotensin-converting Enzyme (ACE)
Chk
Cadherin
Norepinephrine
Indoleamine 2,3-Dioxygenase (IDO)
Lipid
Beta-Secretase
Acyltransferase
Prostaglandin Receptor
TLR
Trk receptor
Urea Transporter
AIM2
Histone Acetyltransferase
PAI-1
ALK
Methionine Adenosyltransferase (MAT)
p62
TMV
Retinoid Receptor
KLF
PI4K
CRISPR/Cas9
PLK
Cuproptosis
SGK
BMI-1
DNA Methyltransferase
Liposome
AhR
NOD-like Receptor (NLR)
CFTR
Monoamine Oxidase

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