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Anti-ITGA4 Antibody (6M773)
😃Good
Catalog No. TMAH-00642
Alias VLA-4 subunit alpha, ITGA 4, Integrin alpha-IV, Integrin alpha-4, CD49D, CD49 antigen-like family member D, CD antigen CD49d
Anti-ITGA4 Antibody (6M773) is an antibody targeting ITGA4. Anti-ITGA4 Antibody (6M773) can be used in ELISA, WB.
Anti-ITGA4 Antibody (6M773)
Anti-ITGA4 Antibody (6M773)
😃Good
Catalog No. TMAH-00642Alias VLA-4 subunit alpha, ITGA 4, Integrin alpha-IV, Integrin alpha-4, CD49D, CD49 antigen-like family member D, CD antigen CD49d
Anti-ITGA4 Antibody (6M773) is an antibody targeting ITGA4. Anti-ITGA4 Antibody (6M773) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, WB Reactivity: Human |
| Alias | VLA-4 subunit alpha, ITGA 4, Integrin alpha-IV, Integrin alpha-4, CD49D, CD49 antigen-like family member D, CD antigen CD49d |
| Ig Type | Rabbit IgG |
| Clone | 6M773 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: Jurkat whole cell lysate -All lanes: ITGA4 antibody at 1:1500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 115, 26 kDa -Observed band size: 140 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Integrin alpha 4 |
| Antigen Species | Human |
| Gene ID | 3676 |
| Uniprot ID | |
| Biology Area | Cardiovascular, Immunology, Signal transduction, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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