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Sertaconazole

Name: Sertaconazole
Brand: TargetMol
SKU: T50005
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T50005Cas No. 99592-32-2

Sertaconazole is a broad-spectrum antifungal.

Sertaconazole

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Purity: 99.48%

Catalog No. T50005Cas No. 99592-32-2

Sertaconazole is a broad-spectrum antifungal.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$53	In Stock	In Stock
10 mg	$75	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$192	In Stock	In Stock
100 mg	$287	In Stock	In Stock
200 mg	$431	-	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.48%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Sertaconazole AI Summary

Sertaconazole exhibits a diverse array of bioactivities. It has no significant hepatic side effects according to the DILIps training set, with multiple hepatic parameters scoring 0.0, indicating no bioactivity related to liver injury or dysfunction. It acts as an inhibitor of mouse Ido2 in HEK293T cells, using L-tryptophan as a substrate and achieving an inhibition of ≥ 55.0% at 20 µM. The compound also inhibits IDO1, with an IC50 value of 8400.0 nM, and exhibits cytotoxicity against mouse P815B cells with an LD50 of 10.0 µM. Additionally, it is soluble up to 10000.0 nM in pH 6.5 phosphate buffer with 5% DMSO. For antiviral activity, Sertaconazole has limited effectiveness against SARS-CoV-2, with a low hit score of 0.03803, 2.98% inhibition of 3CL-Pro protease at 20 µM, and inhibition of virus-induced cytotoxicity in VERO-6 cells showing an IC50 greater than 20000.0 nM. Furthermore, Sertaconazole inhibits equine serum butyrylcholinesterase and human IDO1 with IC50 values of 7400.0 nM and 3800.0 nM, respectively. It also shows inhibitory activity against human HDAC6 enzyme with inhibition values of -25.26% on a commercial peptide substrate and -3.77% on a custom peptide substrate. The compound has binding affinities towards multiple receptors, including human DRD1, KCNH2, SLC6A3, SLC6A2, SLC6A4, ADRA2A, OPRM1, DRD3, CHRM2, ADORA3, HRH3, AR, PGR, and GABRA1, and demonstrates antagonist activity at human TBXA2R and CHRM1, as well as agonist activity at human ADRA1A and TBXA2R. It also inhibits human PTGS1 and PDE4A..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Sertaconazole is a broad-spectrum antifungal.

Chemical Properties

Molecular Weight	437.77
Formula	C₂₀H₁₅Cl₃N₂OS
Cas No.	99592-32-2
Smiles	C(OC(CN1C=CN=C1)C2=C(Cl)C=C(Cl)C=C2)C=3C=4C(SC3)=C(Cl)C=CC4
Relative Density.	1.43g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (125.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2843 mL	11.4215 mL	22.8430 mL	114.2152 mL
5 mM	0.4569 mL	2.2843 mL	4.5686 mL	22.8430 mL
10 mM	0.2284 mL	1.1422 mL	2.2843 mL	11.4215 mL
20 mM	0.1142 mL	0.5711 mL	1.1422 mL	5.7108 mL
50 mM	0.0457 mL	0.2284 mL	0.4569 mL	2.2843 mL
100 mM	0.0228 mL	0.1142 mL	0.2284 mL	1.1422 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc