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LG-100064

Name: LG-100064
Brand: TargetMol
SKU: T11844
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11844Cas No. 153559-46-7

LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)

LG-100064

🥰Excellent

Purity: 98.65%

Catalog No. T11844Cas No. 153559-46-7

LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)

Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$64	In Stock
10 mg	$98	In Stock
25 mg	$176	In Stock
50 mg	$262	In Stock
100 mg	$389	In Stock
200 mg	$573	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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Batch Information

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Purity:98.65%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
Targets&IC50	RXRβ:200 nM (EC50), RXRα:330 nM (EC50), RXRγ:260 nM (EC50)
In vitro	LG-100064 shows no effect on RARα/β/γ (EC50, >10000 nM)[1].LG-100064 (3-Methyl-TTNCB) is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ.

Chemical Properties

Molecular Weight	350.45
Formula	C₂₃H₂₆O₃
Cas No.	153559-46-7
Smiles	Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Relative Density.	1.095

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49 mg/mL (139.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8535 mL	14.2674 mL	28.5347 mL	142.6737 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL	28.5347 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL	14.2674 mL
20 mM	0.1427 mL	0.7134 mL	1.4267 mL	7.1337 mL
50 mM	0.0571 mL	0.2853 mL	0.5707 mL	2.8535 mL
100 mM	0.0285 mL	0.1427 mL	0.2853 mL	1.4267 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc