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L-745870 trihydrochloride
🥰Excellent
Catalog No. T22904Cas No. 866021-03-6
Alias L-745,870 trihydrochloride
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
L-745870 trihydrochloride
🥰Excellent
Purity: 97.52%
Catalog No. T22904Alias L-745,870 trihydrochlorideCas No. 866021-03-6
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $41 | In Stock | In Stock | |
| 5 mg | $89 | In Stock | In Stock | |
| 10 mg | $127 | In Stock | In Stock | |
| 25 mg | $292 | In Stock | In Stock | |
| 50 mg | $418 | In Stock | In Stock | |
| 100 mg | $592 | In Stock | In Stock | |
| 200 mg | $783 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.52%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist. |
| Targets&IC50 | D3 receptor:2300 nM (Ki), D4 receptor:4.3 nM (Ki), D2 receptor:960 nM (Ki) |
| In vivo | L-745870 has favorable pharmacokinetic properties in both rats and monkeys, and shows excellent brain permeability and a high brain-to-plasma ratio in rats [1]. L-745870 (10 mg/kg p.o.) at 30 mg/kg caused mild sedation and extrapyramidal motor symptoms, especially bradykinesia, following oral administration to squirrel monkeys. Lower doses of L-745870 had no apparent behavioral effects in monkeys [1]. |
| Synonyms | L-745,870 trihydrochloride |
| Molecular Weight | 436.21 |
| Formula | C18H22Cl4N4 |
| Cas No. | 866021-03-6 |
| Smiles | ClC1=CC=C(C=C1)N2CCN(CC2)CC3=CNC4=C3C=CC=N4.Cl.Cl.Cl |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (114.62 mM), Sonication is recommended.  H2O: < 40 mg/mL, Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α-adrenoceptorsα-adrenergic receptorSigmareceptorSigma receptororallyL-745870 trihydrochlorideL745870 trihydrochlorideL-745870L745870L-745,870 TrihydrochlorideL-745,870L 745870 trihydrochlorideL 745870InhibitorinhibitDopamineReceptorDopamine ReceptorD4-receptorD4D3D2brain-penetrantAntipsychoticAdrenergicReceptorAdrenergic Receptor5HTReceptor5-HT25HT Receptor
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