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L-745870 trihydrochloride
🥰Excellent
Catalog No. T22904Cas No. 866021-03-6
Alias L-745,870 trihydrochloride
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
L-745870 trihydrochloride
🥰Excellent
Purity: 97.52%
Catalog No. T22904Alias L-745,870 trihydrochlorideCas No. 866021-03-6
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $127 | In Stock | |
| 25 mg | $292 | In Stock | |
| 50 mg | $418 | In Stock | |
| 100 mg | $592 | In Stock | |
| 200 mg | $783 | In Stock |
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Purity:97.52%
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Product Introduction
Bioactivity
Chemical Properties
| Description | L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist. |
| Targets&IC50 | D4 receptor:4.3 nM (Ki), D2 receptor:960 nM (Ki), D3 receptor:2300 nM (Ki) |
| In vivo | L-745870 has favorable pharmacokinetic properties in both rats and monkeys, and shows excellent brain permeability and a high brain-to-plasma ratio in rats [1]. L-745870 (10 mg/kg p.o.) at 30 mg/kg caused mild sedation and extrapyramidal motor symptoms, especially bradykinesia, following oral administration to squirrel monkeys. Lower doses of L-745870 had no apparent behavioral effects in monkeys [1]. |
| Synonyms | L-745,870 trihydrochloride |
| Molecular Weight | 436.21 |
| Formula | C18H22Cl4N4 |
| Cas No. | 866021-03-6 |
| Smiles | ClC1=CC=C(C=C1)N2CCN(CC2)CC3=CNC4=C3C=CC=N4.Cl.Cl.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 40 mg/mL, Sonication is recommended. DMSO: 50 mg/mL (114.62 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α-adrenoceptorsα-adrenergic receptorSigmareceptorSigma receptororallyL-745870 trihydrochlorideL-745870 TrihydrochlorideL745870 trihydrochlorideL745870 TrihydrochlorideL-745870L745870L-745,870 TrihydrochlorideL-745,870L 745870 trihydrochlorideL 745870 TrihydrochlorideL 745870InhibitorinhibitDopamineReceptorDopamine ReceptorD4-receptorD4D3D2brain-penetrantAntipsychoticAdrenergicReceptorAdrenergic Receptor5HTReceptor5-HT25HT Receptor
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