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KL201

Name: KL201
Brand: TargetMol
SKU: T9608
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9608Cas No. 302939-48-6

KL201, a circadian clock modulator, is an isoform-selective cryptochrome 1 (CRY1) stabilizer that lengthens the period of circadian rhythms in cells and tissues [1].

KL201

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Purity: 98%

Catalog No. T9608Cas No. 302939-48-6

KL201, a circadian clock modulator, is an isoform-selective cryptochrome 1 (CRY1) stabilizer that lengthens the period of circadian rhythms in cells and tissues [1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$156	In Stock	In Stock
10 mg	$249	In Stock	In Stock
25 mg	$493	In Stock	In Stock
50 mg	$745	In Stock	In Stock
100 mg	$987	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

KL201, a circadian clock modulator, is an isoform-selective cryptochrome 1 (CRY1) stabilizer that lengthens the period of circadian rhythms in cells and tissues [1].

In vitro

KL201 induces a dose-dependent extension of the circadian cycle in both Bmal1-dLuc and Per2-dLuc reporter cells, with a more pronounced reduction in the luminosity of the Per2-dLuc reporter compared to Bmal1-dLuc, without compromising cell viability[1]. It interacts with CRY1, coinciding with the FBXL3 segment of the ubiquitin ligase complex, and its circadian-modulating effects are diminished by the silencing of FBXL3[1]. Moreover, KL201 extends the circadian rhythm and diminishes the brightness of the Per2::Luc reporter in mouse lung primary explants[1].

Chemical Properties

Molecular Weight	388.28
Formula	C₁₇H₁₄BrN₃OS
Cas No.	302939-48-6
Smiles	Brc1ccccc1C(=O)Nc1ncnc2sc3CCCCc3c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (643.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (8.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5755 mL	12.8773 mL	25.7546 mL	128.7731 mL
5 mM	0.5151 mL	2.5755 mL	5.1509 mL	25.7546 mL
10 mM	0.2575 mL	1.2877 mL	2.5755 mL	12.8773 mL
20 mM	0.1288 mL	0.6439 mL	1.2877 mL	6.4387 mL
50 mM	0.0515 mL	0.2575 mL	0.5151 mL	2.5755 mL
100 mM	0.0258 mL	0.1288 mL	0.2575 mL	1.2877 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc