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JNJ0966

Name: JNJ0966
Brand: TargetMol
SKU: T4783
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4783Cas No. 315705-75-0

JNJ0966 is a highly selective [MMP-9 zymogen] inhibitor with an IC50 of 440 nM.

JNJ0966

🥰Excellent

Purity: 99.62%

Catalog No. T4783Cas No. 315705-75-0

JNJ0966 is a highly selective [MMP-9 zymogen] inhibitor with an IC50 of 440 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$41	In Stock	In Stock
10 mg	$62	In Stock	In Stock
25 mg	$135	In Stock	In Stock
50 mg	$243	In Stock	In Stock
100 mg	$350	-	In Stock
200 mg	$482	-	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.62%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	JNJ0966 is a highly selective [MMP-9 zymogen] inhibitor with an IC50 of 440 nM.
Targets&IC50	MMP9 zymogen:440 nM
In vitro	The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species[1].
In vivo	JNJ0966 demonstrated effectiveness in alleviating the severity of disease in a mouse model of experimental autoimmune encephalomyelitis. Its effectiveness is dose-dependent, showing plasma and brain concentrations of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM) at a 10-mg/kg dose, and 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in the brain at a 30-mg/kg dose, respectively. Moreover, JNJ0966 exhibits a preference for accumulation in the brain, evidenced by brain/plasma ratios of 6.2 at the 10 mg/kg dose and 4.7 at the 30 mg/kg dose.

Chemical Properties

Molecular Weight	360.45
Formula	C₁₆H₁₆N₄O₂S₂
Cas No.	315705-75-0
Smiles	COc1ccccc1Nc1nc(cs1)-c1sc(NC(C)=O)nc1C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (416.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.16 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7743 mL	13.8715 mL	27.7431 mL	138.7155 mL
5 mM	0.5549 mL	2.7743 mL	5.5486 mL	27.7431 mL
10 mM	0.2774 mL	1.3872 mL	2.7743 mL	13.8715 mL
20 mM	0.1387 mL	0.6936 mL	1.3872 mL	6.9358 mL
50 mM	0.0555 mL	0.2774 mL	0.5549 mL	2.7743 mL
100 mM	0.0277 mL	0.1387 mL	0.2774 mL	1.3872 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc