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Anti-PDGFRA Antibody (5Q226)
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Catalog No. TMAY-03579
Alias platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide
Anti-PDGFRA Antibody (5Q226) is a Rabbit antibody targeting PDGFRA. Anti-PDGFRA Antibody (5Q226) can be used in ELISA,IHC-P.
Anti-PDGFRA Antibody (5Q226)
Anti-PDGFRA Antibody (5Q226)
😃Good
Catalog No. TMAY-03579Alias platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide
Anti-PDGFRA Antibody (5Q226) is a Rabbit antibody targeting PDGFRA. Anti-PDGFRA Antibody (5Q226) can be used in ELISA,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PDGFRA Antibody (5Q226) is a Rabbit antibody targeting PDGFRA. Anti-PDGFRA Antibody (5Q226) can be used in ELISA,IHC-P. |
| Alias | platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5Q226 |
| Reactivity | Mouse |
| Verified Activity | 1. Immunochemical staining of Mouse PDGFRA in Mouse blindgut with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of Mouse PDGFRA in Mouse uterus with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PDGF alpha receptor/PDGFRA (rM PDGF alpha receptor/PDGFRA; TMPY-05787; NP_001334647.1; Met1-Ala528). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse PDGF alpha receptor/PDGFRA Protein (TMPY-05787) |
| Antigen Species | Mouse |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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