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Quetiapine
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Catalog No. T0162Cas No. 111974-69-7
Alias Quetiapin, ICI204636
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor.
Quetiapine
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Purity: 99.96%
Catalog No. T0162Alias Quetiapin, ICI204636Cas No. 111974-69-7
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $50 | In Stock | In Stock | |
| 50 mg | $90 | In Stock | In Stock | |
| 100 mg | $117 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.96%
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Product Introduction
Quetiapine AI Summary
Quetiapine exhibits a broad spectrum of bioactivities primarily through interactions with various neurotransmitter receptors. It shows high affinity for dopamine receptors D1, D2, D3, and D4, with particularly strong binding to the D2 receptor (Ki = 63.1 nM). Additionally, it binds to several serotonin receptors, including 5-HT1A (Ki = 79.43 nM) and 5-HT2A (Ki = 63.1 nM), indicating significant neuromodulatory potential. The compound also demonstrates noteworthy binding to histamine H1 (Ki = 39.81 nM) and adrenergic alpha-1 (Ki = 12.59 nM) receptors, showing potential implications in both the dopaminergic and serotonergic systems.
In vivo efficacy is shown in animal models where Quetiapine antagonizes apomorphine-induced climbing and stereotypy behaviors in mice (ED50 values of 51.0 and 60.0 μmol/kg, respectively), as well as reducing dyskinesias in haloperidol-sensitized cebus monkeys in a dose-dependent manner. The compound also affects various physiological processes, impacting liver and kidney functions, bioavailability via BBB penetration (Kp = 8.5), and shows moderate binding to the human estrogen receptor.
Moreover, Quetiapine has been involved in various functional assays demonstrating: H1 receptor antagonism (IC50 = 40.0 nM), serotonin receptor antagonism in the 5-HT2A receptor (IC50 = 31.0 nM), and has properties suggesting low hepatotoxicity as per the Drug Induced Liver Injury Prediction System. Its pharmacokinetic profile includes low excretion, a terminal half-life of approximately 6 hours in humans, and strong brain-binding affinity which may point towards its potential central nervous system effects.
Antiviral activities are noted against SARS-CoV-2, with moderate potency (IC50 > 19952.62 nM). Additionally, the compound shows modest antiproliferative activity against human PC3 cells and exhibits other bioactivities, such as inhibition of the L-type calcium channel and human HDAC6 enzyme. These diverse interactions make Quetiapine a compound of interest for further pharmacological research and development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor. |
| Targets&IC50 | 5-HT2A receptor:7.54 (pKi), 5-HT2C receptor:5.55 (pKi), 5-HT1A receptor:4.77 (pEC50), 5-HT1A receptor:5.74 (pKi), D2 Receptor:7.25 (pKi), D2 Receptor:6.33 (pIC50) |
| Synonyms | Quetiapin, ICI204636 |
| Molecular Weight | 383.51 |
| Formula | C21H25N3O2S |
| Cas No. | 111974-69-7 |
| Smiles | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 |
| Relative Density. | 1.27 g/cm3 |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 120 mg/mL (312.9 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.21 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Serotonin ReceptorQuetiapinemAChRInhibitorinhibitICI-204636ICI 204636HistamineReceptorHistamine ReceptorH1 receptorDopamineReceptorDopamine ReceptorDopamineanxiolyticAntidepressantAdrenergicReceptorAdrenergic Receptor5-hydroxytryptamine Receptor5HTReceptor5-HT2C5-HT2A5-HT1A5-HT Receptor5HT Receptor5-HT
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