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Quetiapine

🥰Excellent
Catalog No. T0162Cas No. 111974-69-7
Alias Quetiapin, ICI204636

Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor.

Quetiapine
Other Forms of Quetiapine:

Quetiapine

🥰Excellent
Purity: 99.63%
Catalog No. T0162Alias Quetiapin, ICI204636Cas No. 111974-69-7
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$50In StockIn Stock
50 mg$90In StockIn Stock
100 mg$117-In Stock
1 mL x 10 mM (in DMSO)$50In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.63%
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Product Introduction

Bioactivity
Description
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor.
Targets&IC50
5-HT1A receptor:5.74 (pKi), 5-HT1A receptor:4.77 (pEC50), D2 Receptor:7.25 (pKi), 5-HT2A receptor:7.54 (pKi), 5-HT2C receptor:5.55 (pKi), D2 Receptor:6.33 (pIC50)
SynonymsQuetiapin, ICI204636
Chemical Properties
Molecular Weight383.51
FormulaC21H25N3O2S
Cas No.111974-69-7
SmilesOCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
Relative Density.1.27 g/cm3
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 45 mg/mL (117.34 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.21 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6075 mL13.0375 mL26.0749 mL130.3747 mL
5 mM0.5215 mL2.6075 mL5.2150 mL26.0749 mL
10 mM0.2607 mL1.3037 mL2.6075 mL13.0375 mL
20 mM0.1304 mL0.6519 mL1.3037 mL6.5187 mL
50 mM0.0521 mL0.2607 mL0.5215 mL2.6075 mL
100 mM0.0261 mL0.1304 mL0.2607 mL1.3037 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

Serotonin ReceptorQuetiapinemAChRInhibitorinhibitICI-204636ICI 204636HistamineReceptorHistamine ReceptorH1 receptorDopamineReceptorDopamine ReceptorDopamineanxiolyticAntidepressantAdrenergicReceptorAdrenergic Receptor5-hydroxytryptamine Receptor5HTReceptor5-HT2C5-HT2A5-HT1A5-HT Receptor5HT Receptor5-HT
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