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Anti-Gclc Antibody (9K428)
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Catalog No. TMAC-01634
Alias Glutamate--cysteine ligase catalytic subunit, Glclc, GCS heavy chain, Gclc, Gamma-glutamylcysteine synthetase, Gamma-ECS
Anti-Gclc Antibody (9K428) is a Rabbit antibody targeting Gclc. Anti-Gclc Antibody (9K428) can be used in WB,IHC,FCM.
Anti-Gclc Antibody (9K428)
Anti-Gclc Antibody (9K428)
😃Good
Catalog No. TMAC-01634Alias Glutamate--cysteine ligase catalytic subunit, Glclc, GCS heavy chain, Gclc, Gamma-glutamylcysteine synthetase, Gamma-ECS
Anti-Gclc Antibody (9K428) is a Rabbit antibody targeting Gclc. Anti-Gclc Antibody (9K428) can be used in WB,IHC,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Chemical Properties
| Description | Anti-Gclc Antibody (9K428) is a Rabbit antibody targeting Gclc. Anti-Gclc Antibody (9K428) can be used in WB,IHC,FCM. |
| Synonyms | Glutamate--cysteine ligase catalytic subunit, Glclc, GCS heavy chain, Gclc, Gamma-glutamylcysteine synthetase, Gamma-ECS |
| Ig Type | IgG |
| Clone | 9K428 |
| Reactivity | Human,Rat |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The GCLC gene consists of 16 exons and encodes the 636 amino acid protein g-GCSc (g-glutamylcysteine synthetase heavy subunit), also designated g-L-glutamate-L-cysteine ligase catalytic subunit (GLCLC). g-GCSc is expressed in hemocytes, brain, liver and kidney. g-GCSc associates with a regulatory or modifier subunit, g-GCSm (g-glutamylcysteine synthetase light subunit), to form a heterodimer, g-GCS. g-GCS is the first enzyme involved and the rate determining step in glutathione biosynthesis. Oxidants, cadium and methyl mercury upregulate the transcription of g-GCS. H2O2 regulation depends on the Yap1 protein and the presence of glutamate, glutamine and lysine. Cadium regulates transcription through proteins Met-4, Met-31 and Met-32. Cbf1, a DNA binding protein, inhibits transcription of g-GCS. Chemopreventive compounds cause increased levels of g-GCSc in kidney tissues, which may protect against chemically induced carcinogenesis. A His370Leu amino acid change in g-GCSc causes deficiencies in activity which are responsible for hemolytic anemia and low red blood cell glutathione levels. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 73 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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