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PF-06843195

Name: PF-06843195
Brand: TargetMol
SKU: T36308
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36308Cas No. 2067281-51-8

Alias PF06843195

PF-06843195 is a potent and selective PI3Kα inhibitor that binds to the active site of PI3Kα and prevents it from catalyzing the conversion of PIP2 to PIP3, thereby inhibiting the activation of AKT, with anti-tumor activity in vitro and in vivo.

PF-06843195

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Purity: 98.01%

Catalog No. T36308Alias PF06843195Cas No. 2067281-51-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$99	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.01%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	PF-06843195 is a potent and selective PI3Kα inhibitor that binds to the active site of PI3Kα and prevents it from catalyzing the conversion of PIP2 to PIP3, thereby inhibiting the activation of AKT, with anti-tumor activity in vitro and in vivo.
Targets&IC50	PI3Kδ:160 nM (IC50, in Rat1 fibroblasts), PI3Kδ:0.28 nM (Ki), PI3Kα:0.018 nM (Ki)
In vitro	PF-06843195 is able to inhibit the proliferation of T47D and MCF7 cells with IC50 values of 32 nM and 62 nM, respectively. [1]
In vivo	Methods: PF-06843195 (10 mg/kg, oral) and (2 mg/kg, intravenous) were used to treat rats and study its pharmacokinetics. Results: It showed excellent bioavailability (25%) after oral administration and high plasma clearance (30 mL/min/kg) and large distribution volume (3.0 L/kg) after intravenous injection. [1]
Synonyms	PF06843195

Chemical Properties

Molecular Weight	498.46
Formula	C₂₀H₂₅F₃N₈O₄
Cas No.	2067281-51-8
Smiles	N([C@]1(CO)CN(C(OCC(F)F)=O)CC1)C=2C(F)=C(N=C(N2)N3CCOCC3)C=4C=NC(N)=NC4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (100.31 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0062 mL	10.0309 mL	20.0618 mL	100.3090 mL
5 mM	0.4012 mL	2.0062 mL	4.0124 mL	20.0618 mL
10 mM	0.2006 mL	1.0031 mL	2.0062 mL	10.0309 mL
20 mM	0.1003 mL	0.5015 mL	1.0031 mL	5.0154 mL
50 mM	0.0401 mL	0.2006 mL	0.4012 mL	2.0062 mL
100 mM	0.0201 mL	0.1003 mL	0.2006 mL	1.0031 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc