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9-Phenanthrol

🥰Excellent
Catalog No. T22537Cas No. 484-17-3

9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.

9-Phenanthrol

9-Phenanthrol

🥰Excellent
Purity: 98.48%
Catalog No. T22537Cas No. 484-17-3
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$40In StockIn Stock
50 mg$52In StockIn Stock
100 mg$73In StockIn Stock
200 mg$97In Stock-
1 mL x 10 mM (in DMSO)$39In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.48%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.
In vitro
In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5[1].
Chemical Properties
Molecular Weight194.23
FormulaC14H10O
Cas No.484-17-3
SmilesOc1cc2ccccc2c2ccccc12
Relative Density.1.244g/cm3
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 19 mg/mL (97.82 mM), Sonication is recommended.
Ethanol: 9 mg/mL (46.34 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM5.1485 mL25.7427 mL51.4854 mL257.4268 mL
5 mM1.0297 mL5.1485 mL10.2971 mL51.4854 mL
10 mM0.5149 mL2.5743 mL5.1485 mL25.7427 mL
20 mM0.2574 mL1.2871 mL2.5743 mL12.8713 mL
DMSO
1mg5mg10mg50mg
50 mM0.1030 mL0.5149 mL1.0297 mL5.1485 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

TRPVChannelTRPV ChannelTRPM4TRPChannelTRP ChannelTransient receptor potential channelsNSC-50554NSC50554NSC 50554ischemia-reperfusion injuryInhibitorinhibit9-Phenanthrol9Phenanthrol9-Hydroxyphenanthrene9 Phenanthrol
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