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Anti-HMGCR Polyclonal Antibody (Synonyms: HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A redu...)

Catalog No. TMAB-00872 Copy Product Info
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Anti-HMGCR Polyclonal Antibody is a Rabbit antibody targeting HMGCR. Anti-HMGCR Polyclonal Antibody can be used in WB.

Anti-HMGCR Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-00872
Synonyms HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Anti-HMGCR Polyclonal Antibody is a Rabbit antibody targeting HMGCR. Anti-HMGCR Polyclonal Antibody can be used in WB.

Anti-HMGCR Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2207-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5297-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-HMGCR Polyclonal Antibody is a Rabbit antibody targeting HMGCR. Anti-HMGCR Polyclonal Antibody can be used in WB.
SynonymsHMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Ig Type
IgG
Reactivity
Human
Verified Activity
25 μg total protein per Lane of various lysates probed with HMGCR polyclonal antibody, unconjugated (TMAB-00872) at 1:2000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.
verifiedActivity
Application
WB
Recommended Dose
WB=1:1000-5000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationEndoplasmic reticulum membrane. Peroxisome membrane.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundHMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human HMGCR
Antigen Species
Human
Gene Name
HMGCR
Gene ID
3156
Protein Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Uniprot ID
P04035
Biology Area
Metabolism of lipids and lipoproteins,Lipoprotein metabolism,Cholesterol Metabolism,Cholesterol Metabolism,Lipid metabolism,Lipoprotein metabolism,Heart disease,Lipid metabolism
Function
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.
Chemical Properties
Molecular WeightTheoretical: 97 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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