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Fosphenytoin disodium

Name: Fosphenytoin disodium
Brand: TargetMol
SKU: T7066
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7066Cas No. 92134-98-0

Alias Fosphenytoin sodium, ACC-9653

Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker

Fosphenytoin disodium

🥰Excellent

Purity: 99.97%

Catalog No. T7066Alias Fosphenytoin sodium, ACC-9653Cas No. 92134-98-0

Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker

Pack Size	Price	Availability
10 mg	$31	In Stock
25 mg	$58	In Stock
50 mg	$90	In Stock
100 mg	$132	In Stock
500 mg	$328	In Stock

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Batch Information

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Purity:99.97%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker
In vivo	Fosphenytoin has anticonvulsant activity in a mouse model of maximal electroshock seizures similar to that of phenytoin (ED50s = 16 and 8 mg/kg, respectively). It also has antiarrhythmic activity in isolated guinea pig atria and in anesthetized dogs. Formulations containing fosphenytoin have been used in the treatment of status epilepticus
Synonyms	Fosphenytoin sodium, ACC-9653

Chemical Properties

Molecular Weight	406.24
Formula	C₁₆H₁₃N₂Na₂O₆P
Cas No.	92134-98-0
Smiles	O.[Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C1=O)(c1ccccc1)c1ccccc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (246.16 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.4616 mL	12.3080 mL	24.6160 mL	123.0800 mL
5 mM	0.4923 mL	2.4616 mL	4.9232 mL	24.6160 mL
10 mM	0.2462 mL	1.2308 mL	2.4616 mL	12.3080 mL
20 mM	0.1231 mL	0.6154 mL	1.2308 mL	6.1540 mL
50 mM	0.0492 mL	0.2462 mL	0.4923 mL	2.4616 mL
100 mM	0.0246 mL	0.1231 mL	0.2462 mL	1.2308 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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