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Rhodojaponin III
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Catalog No. T5S0527Cas No. 26342-66-5
1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodojaponin III induces a certain linkage for change of [Ca2+](i), cell cycle arrest, proliferation inhibition in Sf9 cells.
Rhodojaponin III
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Purity: 99.91%
Catalog No. T5S0527Cas No. 26342-66-5
1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodojaponin III induces a certain linkage for change of [Ca2+](i), cell cycle arrest, proliferation inhibition in Sf9 cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $56 | In Stock | In Stock | |
| 5 mg | $135 | In Stock | In Stock | |
| 10 mg | $222 | In Stock | In Stock | |
| 25 mg | $375 | In Stock | In Stock | |
| 50 mg | $557 | In Stock | In Stock | |
| 100 mg | $783 | - | In Stock | |
| 200 mg | $1,090 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $153 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.91%
Appearance:Solid
Color:White
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Product Introduction
Rhodojaponin III AI Summary
Rhodojaponin III exhibits multiple bioactivities including significant antinociceptive and anti-inflammatory effects. It has a toxicity LD50 of 0.271 mg/kg when administered intraperitoneally in Kunming mice. The compound demonstrates potent antinociceptive activity with an ID50 of 0.0469 mg/kg in an acute pain model, inhibiting 73.7% of acetic acid-induced writhes at 0.08 mg/kg dose. It has a favorable selectivity index of 5.8, indicating a good balance between effectiveness and toxicity. In a model of STZ-induced diabetic neuropathy in Kunming mice, Rhodojaponin III increases the paw withdrawal mechanical threshold at oral doses between 0.2 and 0.4 mg/kg, comparing favorably with gabapentin. In terms of anti-inflammatory activity, it inhibits LPS-induced nitric oxide production in mouse RAW264.7 cells with an IC50 of 7000.0 nM. Additionally, at 40 uM, it significantly reduces nitric oxide production by more than 50%. The compound exhibits low cytotoxicity, with cell survival rates of 96.5% and 98.4% at 200 uM without and with LPS, respectively..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodojaponin III induces a certain linkage for change of [Ca2+](i), cell cycle arrest, proliferation inhibition in Sf9 cells. |
| Molecular Weight | 368.46 |
| Formula | C20H32O6 |
| Cas No. | 26342-66-5 |
| Smiles | C[C@@]1(O)C[C@@]23C[C@@H](O)[C@@]4(O)[C@@H]([C@@H]5O[C@@H]5C4(C)C)[C@](C)(O)[C@@H]2CC[C@@H]1[C@H]3O |
| Relative Density. | 1.40 g/cm3 at 20℃ |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 3.69 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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