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Atractylenolide III

Name: Atractylenolide III
Brand: TargetMol
SKU: T3902
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3902Cas No. 73030-71-4

Alias ICodonolactone, 8β-Hydroxyasterolide

Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung carcinoma by inducing the release of cytochrome c, upregulating the expression of Bax and translocating apoptosis-inducing factor.

Atractylenolide III

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Purity: 99.98%

Catalog No. T3902Alias ICodonolactone, 8β-HydroxyasterolideCas No. 73030-71-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$51	In Stock	In Stock
10 mg	$79	In Stock	In Stock
25 mg	$129	In Stock	In Stock
50 mg	$189	In Stock	In Stock
100 mg	$283	In Stock	In Stock
200 mg	$419	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Atractylenolide III AI Summary

Atractylenolide III exhibits multiple bioactivities across various biological systems. It demonstrates antihepatotoxic activity by reducing carbon tetrachloride and galactosamine-induced cytotoxicity in rat hepatocytes, indicating effectiveness at 1 mg/mL with GPT activity levels at 103.0% and 97.0% of the control, respectively. Although it shows no significant inhibitory activity against 5-lipoxygenase and COX1 (IC50 > 200,000 nM), it has notable agonist activity at human PR in HepG2 cells, enhancing MMTV gene promoter transactivation and luciferase activity at 10 µM and 100 µM. Conversely, it acts as an antagonist at human FXR, inhibiting CDCA-induced SHP gene transactivation in a dose-dependent manner (10 µM, 50 µM, 100 µM). In inflammatory models, it has weak antiinflammatory activity, reducing LPS-induced nitric oxide production in mouse RAW264.7 cells (IC50 > 100,000 nM). Neuroprotective effects are observed against glutamate-induced neuronal cell death in rat PC12 cells with an EC50 value of 36,300 nM. Additionally, Atractylenolide III inhibits sterol O-acyltransferase (SOAT) enzymes, showing varied IC50 values across different assays, including 211,000 nM in CHOK1 microsomes, and significant inhibition of cholesterol ester biosynthesis in CHO cells and microsomal fractions, with IC50 values ranging from 55,100 nM to over 195,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung carcinoma by inducing the release of cytochrome c, upregulating the expression of Bax and translocating apoptosis-inducing factor.
Synonyms	ICodonolactone, 8β-Hydroxyasterolide

Chemical Properties

Molecular Weight	248.32
Formula	C₁₅H₂₀O₃
Cas No.	73030-71-4
Smiles	CC1=C2C[C@H]3C(=C)CCC[C@]3(C)C[C@]2(O)OC1=O
Relative Density.	1.18 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble

DMSO: 257.5 mg/mL (1036.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0271 mL	20.1353 mL	40.2706 mL	201.3531 mL
5 mM	0.8054 mL	4.0271 mL	8.0541 mL	40.2706 mL
10 mM	0.4027 mL	2.0135 mL	4.0271 mL	20.1353 mL
20 mM	0.2014 mL	1.0068 mL	2.0135 mL	10.0677 mL
50 mM	0.0805 mL	0.4027 mL	0.8054 mL	4.0271 mL
100 mM	0.0403 mL	0.2014 mL	0.4027 mL	2.0135 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc