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rac-BHFF

Name: rac-BHFF
Brand: TargetMol
SKU: T4176
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4176Cas No. 123557-91-5

Alias (R,S)-BHFF

rac-BHFF ((R,S)-BHFF) is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo and is orally active.

rac-BHFF

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Purity: 99.69%

Catalog No. T4176Alias (R,S)-BHFFCas No. 123557-91-5

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$36	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$497	In Stock	In Stock
200 mg	$692	-	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.69%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

rac-BHFF AI Summary

rac-BHFF exhibits multiple pharmacological activities. It acts as an agonist at the rat GABA-A alpha1beta2gamma2 receptor with an EC50 greater than 100,000 nM when expressed in human TSA201 cells and also shows agonist activity at the human GABA-B B1/B2 receptor in HEK293 cells with an EC50 of 1900 nM. Furthermore, it functions as a positive allosteric modulator at the GABA-B receptor, enhancing GABA-induced [35S]GTPgammaS binding with an efficacy of 149.0%. In terms of antiviral properties, rac-BHFF demonstrates inhibition of SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours, with inhibitory percentages of -7.47% and 1.08%, respectively. It also shows modest inhibition (12.17%) of SARS-CoV-2 3CL-Pro protease activity at 20 µM. Additionally, the compound has an inhibitory effect on human HDAC6, with negative inhibition percentages of -6.8% and -0.22% in assays using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	rac-BHFF ((R,S)-BHFF) is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo and is orally active.
Synonyms	(R,S)-BHFF

Chemical Properties

Molecular Weight	330.34
Formula	C₁₇H₂₁F₃O₃
Cas No.	123557-91-5
Smiles	CC(C)(C)c1cc2c(OC(=O)C2(O)C(F)(F)F)c(c1)C(C)(C)C
Relative Density.	1.232 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (151.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0272 mL	15.1359 mL	30.2718 mL	151.3592 mL
5 mM	0.6054 mL	3.0272 mL	6.0544 mL	30.2718 mL
10 mM	0.3027 mL	1.5136 mL	3.0272 mL	15.1359 mL
20 mM	0.1514 mL	0.7568 mL	1.5136 mL	7.5680 mL
50 mM	0.0605 mL	0.3027 mL	0.6054 mL	3.0272 mL
100 mM	0.0303 mL	0.1514 mL	0.3027 mL	1.5136 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc