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Hederacoside C

Name: Hederacoside C
Brand: TargetMol
SKU: T3370
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3370Cas No. 14216-03-6

Alias Kalopanaxsaponin B, Hederasaponin C

Hederacoside C (Hederasaponin C) is expectorant for Cold and cough relief, Bronchitis.

Hederacoside C

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Purity: 99.93%

Catalog No. T3370Alias Kalopanaxsaponin B, Hederasaponin CCas No. 14216-03-6

Hederacoside C (Hederasaponin C) is expectorant for Cold and cough relief, Bronchitis.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$46	In Stock	In Stock
50 mg	$65	In Stock	In Stock
100 mg	$92	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Hederacoside C AI Summary

Hederacoside C inhibits TNF-alpha-induced NFkappaB activation in human HepG2 cells with an IC50 value of 800.0 nM after 1 hour. It exhibits low cytotoxicity and membrane toxicity against human ECV304 cells, demonstrated by IC50 values greater than 164,000.0 nM in both LDH release and MTT assays after 2 and 72 hours, respectively. Additionally, the compound shows membranolytic activity and reduces surface tension in 0.1 M PBS with an EC50 value of 10,000.0 nM, and has a critical micellar concentration of 82.0 uM in the same medium. Hederacoside C inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells at an equimolar concentration of 10 uM by 127.69% and 109.83%, respectively. It also demonstrates anti-inflammatory activity in mouse RAW264.7 cells by inhibiting LPS-induced nitric oxide production, with an IC50 value greater than 50,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hederacoside C (Hederasaponin C) is expectorant for Cold and cough relief, Bronchitis.
Synonyms	Kalopanaxsaponin B, Hederasaponin C

Chemical Properties

Molecular Weight	1221.38
Formula	C₅₉H₉₆O₂₆
Cas No.	14216-03-6
Smiles	C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(OC[C@H]3O[C@@H](OC(=O)[C@]45CCC(C)(C)C[C@H]4C4=CC[C@@H]6[C@@]7(C)CC[C@H](O[C@@H]8OC[C@H](O)[C@H](O)C8O[C@@H]8O[C@@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@@](C)(CO)[C@@H]7CC[C@@]6(C)[C@]4(C)CC5)[C@H](O)[C@@H](O)[C@@H]3O)O[C@@H]2CO)[C@H](O)[C@H](O)[C@H]1O
Relative Density.	1.48g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (102.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8187 mL	4.0937 mL	8.1875 mL	40.9373 mL
5 mM	0.1637 mL	0.8187 mL	1.6375 mL	8.1875 mL
10 mM	0.0819 mL	0.4094 mL	0.8187 mL	4.0937 mL
20 mM	0.0409 mL	0.2047 mL	0.4094 mL	2.0469 mL
50 mM	0.0164 mL	0.0819 mL	0.1637 mL	0.8187 mL
100 mM	0.0082 mL	0.0409 mL	0.0819 mL	0.4094 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc