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CP 424174

Name: CP 424174
Brand: TargetMol
SKU: T8828
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8828Cas No. 210825-31-3

CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

CP 424174

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🥰Excellent

Catalog No. T8828Cas No. 210825-31-3

CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$127	In Stock	In Stock
25 mg	$212	In Stock	In Stock
50 mg	$315	In Stock	In Stock
100 mg	$469	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:>99.99%

Appearance:solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

CP 424174 AI Summary

CP 424174 demonstrates a bioactivity characterized by reversible inhibition of the NLRP3 inflammasome in LPS-activated human monocytes. Using ELISA analysis in the presence of ATP, the inhibition was observed after 30 minutes, with an IC50 value of 260.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.
Targets&IC50	IL-1β:210 nM

Chemical Properties

Molecular Weight	452.99
Formula	C₂₂H₂₉ClN₂O₄S
Cas No.	210825-31-3
Smiles	CC(C)c1cc(Cl)cc(C(C)C)c1NC(=O)NS(=O)(=O)c1cccc(c1)C(C)(C)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (60.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2076 mL	11.0378 mL	22.0755 mL	110.3777 mL
5 mM	0.4415 mL	2.2076 mL	4.4151 mL	22.0755 mL
10 mM	0.2208 mL	1.1038 mL	2.2076 mL	11.0378 mL
20 mM	0.1104 mL	0.5519 mL	1.1038 mL	5.5189 mL
50 mM	0.0442 mL	0.2208 mL	0.4415 mL	2.2076 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc