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CP 424174

Name: CP 424174
Brand: TargetMol
SKU: T8828
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8828Cas No. 210825-31-3

CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

CP 424174

🥰Excellent

Catalog No. T8828Cas No. 210825-31-3

CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$81	In Stock
10 mg	$127	In Stock
25 mg	$212	In Stock
50 mg	$315	In Stock
100 mg	$469	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Batch Information

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Purity:>99.99%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.
Targets&IC50	IL-1β:210 nM

Chemical Properties

Molecular Weight	452.99
Formula	C₂₂H₂₉ClN₂O₄S
Cas No.	210825-31-3
Smiles	CC(C)c1cc(Cl)cc(C(C)C)c1NC(=O)NS(=O)(=O)c1cccc(c1)C(C)(C)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (60.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2076 mL	11.0378 mL	22.0755 mL	110.3777 mL
5 mM	0.4415 mL	2.2076 mL	4.4151 mL	22.0755 mL
10 mM	0.2208 mL	1.1038 mL	2.2076 mL	11.0378 mL
20 mM	0.1104 mL	0.5519 mL	1.1038 mL	5.5189 mL
50 mM	0.0442 mL	0.2208 mL	0.4415 mL	2.2076 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc