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HZ-1157

Name: HZ-1157
Brand: TargetMol
SKU: T4197
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4197Cas No. 1009734-33-1

Alias HZ1157, DHFR-inhibitor

HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease.

HZ-1157

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Purity: 99.03%

Catalog No. T4197Alias HZ1157, DHFR-inhibitorCas No. 1009734-33-1

HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$159	In Stock	In Stock
50 mg	$233	In Stock	In Stock
100 mg	$345	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.03%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

HZ-1157 AI Summary

HZ-1157 exhibits potent antiviral activity against the Dengue virus serotype 2 (DENV2), with an EC50 of 2.8 nM, effectively reducing viral replication and NS1 antigen-positive cells. This activity has been confirmed in Huh7 cells using a renilla luciferase assay conducted 48 hours post-infection with the New Guinea C strain. The compound shows a high selectivity index, with a CC50/EC50 ratio greater than 1000, indicating low cytotoxicity relative to its antiviral potency. It also demonstrates good oral bioavailability in rats, with a bioavailability (F) value of 69.0%, a moderate half-life of 5.0 hours, and effective plasma clearance. However, HZ-1157 has shown human ERG inhibition with an IC50 of 20200.0 nM, suggesting a potential risk for cardiac side effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease.
Targets&IC50	HCV NS3/4A protease:1.0 μmol/L (IC50)
Synonyms	HZ1157, DHFR-inhibitor

Chemical Properties

Molecular Weight	232.28
Formula	C₁₂H₁₆N₄O
Cas No.	1009734-33-1
Smiles	CC(C)(C)Oc1cccc2nc(N)nc(N)c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (43.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3051 mL	21.5257 mL	43.0515 mL	215.2574 mL
5 mM	0.8610 mL	4.3051 mL	8.6103 mL	43.0515 mL
10 mM	0.4305 mL	2.1526 mL	4.3051 mL	21.5257 mL
20 mM	0.2153 mL	1.0763 mL	2.1526 mL	10.7629 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc