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Chlorindione

Name: Chlorindione
Brand: TargetMol
SKU: T0360
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0360Cas No. 1146-99-2

Alias Indaliton, G-25766, chlophenadione

Chlorindione (chlophenadione) is a vitamin K antagonist, a potent anticoagulant compound.

Chlorindione

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Purity: 99.67%

Catalog No. T0360Alias Indaliton, G-25766, chlophenadioneCas No. 1146-99-2

Chlorindione (chlophenadione) is a vitamin K antagonist, a potent anticoagulant compound.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	In Stock
100 mg	$47	In Stock	-
200 mg	$68	In Stock	-
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.67%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Chlorindione AI Summary

Chlorindione demonstrates a diverse range of bioactivities and pharmacological properties. It inhibits 5-lipoxygenase activity in RBL-1 cells with an IC50 value of 5000.0 nM and shows hypolipidemic effects in CF1 male mice at a dose of 20 mg/kg per day, significantly reducing serum cholesterol levels by 1% on both the 9th and 16th days and decreasing serum triglyceride levels by 47% on the 16th day compared to control. The compound also modulates miRNAs, activates the Rab9 promoter, inhibits influenza NS1 protein function, and affects various other biological targets including Nrf2, G9a, BAZ2B, ELG1-dependent DNA repair, malarial parasite plastid, firefly luciferase, and MBNL1-poly(CUG) RNA binding. Additionally, Chlorindione exhibits uncoupling activity of oxidative phosphorylation in rat liver mitochondria with a log(1/C50) value of 4.2. In terms of antiviral properties, Chlorindione shows inhibition of SARS-CoV-2 induced cytotoxicity in both Caco-2 cells (2.17% inhibition at 10 uM after 48 hours) and VERO-6 cells (0.06% inhibition at 10 uM with an IC50 value > 20000.0 nM). It also inhibits the SARS-CoV-2 3CL-Pro protease with a percentage inhibition of 6.823% at 20 µM. Furthermore, Chlorindione demonstrates inhibitory activity on the human HDAC6 enzyme, achieving an inhibition rate of 18.57% using a commercial peptide substrate but showing a slight negative inhibition of -0.61% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chlorindione (chlophenadione) is a vitamin K antagonist, a potent anticoagulant compound.
Synonyms	Indaliton, G-25766, chlophenadione

Chemical Properties

Molecular Weight	256.68
Formula	C₁₅H₉ClO₂
Cas No.	1146-99-2
Smiles	Clc1ccc(cc1)C1C(=O)c2ccccc2C1=O
Relative Density.	1.2053 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (194.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8959 mL	19.4795 mL	38.9590 mL	194.7951 mL
5 mM	0.7792 mL	3.8959 mL	7.7918 mL	38.9590 mL
10 mM	0.3896 mL	1.9480 mL	3.8959 mL	19.4795 mL
20 mM	0.1948 mL	0.9740 mL	1.9480 mL	9.7398 mL
50 mM	0.0779 mL	0.3896 mL	0.7792 mL	3.8959 mL
100 mM	0.0390 mL	0.1948 mL	0.3896 mL	1.9480 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc