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Pefloxacin Mesylate

Name: Pefloxacin Mesylate
Brand: TargetMol
SKU: T0425
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0425Cas No. 70458-95-6

Alias Pefloxacinium mesylate

Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

Pefloxacin Mesylate

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Purity: 99.86%

Catalog No. T0425Alias Pefloxacinium mesylateCas No. 70458-95-6

Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$33	In Stock	In Stock
500 mg	$56	In Stock	In Stock
1 g	$81	In Stock	In Stock
5 g	$198	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Pefloxacin Mesylate AI Summary

Pefloxacin Mesylate exhibits a wide range of bioactivities including cytotoxic, enzymatic inhibition, antimicrobial, and antiviral properties. It shows cytotoxic effects against Streptococcus with EC50 values of 13354.0 nM and 12120.0 nM. Pefloxacin Mesylate inhibits the Jumonji Domain Containing 2E (JMJD2E) with potencies of 31622.8 nM and 17782.8 nM, and Streptokinase promoter activity with an EC50 of 15102.0 nM. It also targets enzymes such as ALDH1A1, Menin-MLL interaction, HPGD, and the PhoP region in Salmonella Typhimurium with IC50 values between 1000.0 nM and 35481.3 nM. Pefloxacin Mesylate demonstrates significant inhibition of sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells by 95.74% and 123.14% respectively at 10 µM. It also shows antiviral activity against SARS-CoV-2, reducing cytotoxicity in Caco-2 and VERO-6 cells by 27.49% and 0.13% respectively at 10 µM concentration after 48 hours, and inhibits SARS-CoV-2 3CL-Pro protease by 37.67% at 20 µM. In antifungal assays, Pefloxacin Mesylate shows activity against Candida albicans and Cryptococcus neoformans with MIC values greater than 10000.0 nM. Against bacteria, it inhibits Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiella pneumoniae with MIC values from 156.3 nM to 5000.0 nM, though it is ineffective against Acinetobacter baumannii with an MIC of 10000.0 nM. Its cytotoxicity against HEK293 cells is recorded with a CC50 greater than 10000.0 nM. Overall, Pefloxacin Mesylate is a potent inhibitor with applications in cytotoxicity, enzyme inhibition, and antimicrobial and antiviral activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Synonyms	Pefloxacinium mesylate

Chemical Properties

Molecular Weight	429.46
Formula	C₁₈H₂₄FN₃O₆S
Cas No.	70458-95-6
Smiles	n1(cc(c(=O)c2cc(c(cc12)N1CCN(CC1)C)F)C(=O)O)CC.CS(=O)(=O)O
Relative Density.	1.32 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 4.3 mg/mL (10.01 mM), Sonication is recommended.

H2O: 61 mg/mL (142.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3285 mL	11.6425 mL	23.2851 mL	116.4253 mL
5 mM	0.4657 mL	2.3285 mL	4.6570 mL	23.2851 mL
10 mM	0.2329 mL	1.1643 mL	2.3285 mL	11.6425 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1164 mL	0.5821 mL	1.1643 mL	5.8213 mL
50 mM	0.0466 mL	0.2329 mL	0.4657 mL	2.3285 mL
100 mM	0.0233 mL	0.1164 mL	0.2329 mL	1.1643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc