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Anti-EPCR Antibody-APC (9U126)
🥰Excellent
Catalog No. TMAY-03487A
Anti-EPCR Antibody-APC (9U126) is a APC-conjugated Rabbit antibody targeting EPCR. Anti-EPCR Antibody-APC (9U126) can be used in FCM.
Anti-EPCR Antibody-APC (9U126)
Anti-EPCR Antibody-APC (9U126)
🥰Excellent
Catalog No. TMAY-03487A
Anti-EPCR Antibody-APC (9U126) is a APC-conjugated Rabbit antibody targeting EPCR. Anti-EPCR Antibody-APC (9U126) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-EPCR Antibody-APC (9U126) is a APC-conjugated Rabbit antibody targeting EPCR. Anti-EPCR Antibody-APC (9U126) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 9U126 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse PROCR(CD201) expression on bEnd.3 cells. Cells were stained with APC-conjugated anti-Mouse PROCR(CD201). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 1 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Epcr/PROCR (rM Epcr/PROCR; TMPY-02487; Q64695; Met1-Ser214) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found mainly near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depending on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. |
| Conjucates | APC |
| Others Formats | Unconjugated/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Mouse Epcr/PROCR Protein (TMPY-02487) |
| Antigen Species | Mouse |
| Biology Area | Serine Proteases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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