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7-Methylxanthine

Name: 7-Methylxanthine
Brand: TargetMol
SKU: T0543
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0543Cas No. 552-62-5

Alias Heteroxanthine, Heteroxanthin

7-Methylxanthine is a methyl derivative of xanthine, the purine component of human urinary calculi.7-Methylxanthine has an affinity for adenosine receptors.7-Methylxanthine is a methyl derivative of xanthine, the purine component of human urinary calculi.7-Methylxanthine has an affinity for adenosine receptors.

7-Methylxanthine

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Purity: 99.81%

Catalog No. T0543Alias Heteroxanthine, HeteroxanthinCas No. 552-62-5

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$34	In Stock	In Stock
50 mg	$48	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.81%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

7-Methylxanthine AI Summary

7-Methylxanthine demonstrates binding affinity at the Adenosine A1 receptor in rat brain cortical membranes with a Ki of 33,000.0 nM, and at the Adenosine A2 receptor in rat striatal membranes with a Ki of 59,000.0 nM. It also exhibits bioactivity as a GDA inhibitor with a Ki of 5550.0 nM determined through a colorimetric assay. Antiviral activity against SARS-CoV-2 has been observed, including inhibition of virus-induced cytotoxicity in Caco-2 cells at 10 µM, measured by high content imaging, resulting in an inhibition percentage of -5.77%. The compound also showed 10.81% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM using a FRET assay. Additionally, inhibition of cytotoxicity was noted in VERO-6 cells at 10 µM, although the IC50 value exceeded 20,000.0 nM, suggesting limited potency. 7-Methylxanthine's inhibition of human HDAC6 was minimal, showing 9.47% inhibition with a commercial peptide substrate and -2.27% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	7-Methylxanthine is a methyl derivative of xanthine, the purine component of human urinary calculi.7-Methylxanthine has an affinity for adenosine receptors.7-Methylxanthine is a methyl derivative of xanthine, the purine component of human urinary calculi.7-Methylxanthine has an affinity for adenosine receptors.
Synonyms	Heteroxanthine, Heteroxanthin

Chemical Properties

Molecular Weight	166.14
Formula	C₆H₆N₄O₂
Cas No.	552-62-5
Smiles	Cn1cnc2[nH]c(=O)[nH]c(=O)c12
Relative Density.	1.83 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 3.8 mg/mL (22.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0190 mL	30.0951 mL	60.1902 mL	300.9510 mL
5 mM	1.2038 mL	6.0190 mL	12.0380 mL	60.1902 mL
10 mM	0.6019 mL	3.0095 mL	6.0190 mL	30.0951 mL
20 mM	0.3010 mL	1.5048 mL	3.0095 mL	15.0476 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc