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Trometamol hydrochloride

Name: Trometamol hydrochloride
Brand: TargetMol
SKU: T23478
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23478Cas No. 1185-53-1

Alias TRIS hydrochloride

Trometamol hydrochloride (TRIS hydrochloride) (Tromethamine hydrochloride) is a biologically inert amino alcohol with low toxicity. Trometamol hydrochloride buffers carbon dioxide and acids in vitro and in vivo. Trometamol hydrochloride is an effective amine compound for pH control in the physiological range.

Trometamol hydrochloride

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Purity: 99.89%

Catalog No. T23478Alias TRIS hydrochlorideCas No. 1185-53-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Trometamol hydrochloride (TRIS hydrochloride) (Tromethamine hydrochloride) is a biologically inert amino alcohol with low toxicity. Trometamol hydrochloride buffers carbon dioxide and acids in vitro and in vivo. Trometamol hydrochloride is an effective amine compound for pH control in the physiological range.
Synonyms	TRIS hydrochloride

Chemical Properties

Molecular Weight	157.6
Formula	C₄H₁₂ClNO₃
Cas No.	1185-53-1
Smiles	Cl.NC(CO)(CO)CO
Relative Density.	Ca. 1.28 g/cm3. Temperature:20.2 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 630.4 mg/mL, Sonication is recommended.

DMSO: 55 mg/mL (348.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 4 mg/mL (25.38 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3452 mL	31.7259 mL	63.4518 mL	317.2589 mL
5 mM	1.2690 mL	6.3452 mL	12.6904 mL	63.4518 mL
10 mM	0.6345 mL	3.1726 mL	6.3452 mL	31.7259 mL
20 mM	0.3173 mL	1.5863 mL	3.1726 mL	15.8629 mL
50 mM	0.1269 mL	0.6345 mL	1.2690 mL	6.3452 mL
100 mM	0.0635 mL	0.3173 mL	0.6345 mL	3.1726 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc