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Anti-ITGA5 Antibody (3X608)
😃Good
Catalog No. TMAH-00643
Alias VLA-5, ITGA5, Integrin α-F, Integrin α-5, Integrin Alpha-F, Integrin Alpha-5, FNRA, Fibronectin Receptor Subunit α, Fibronectin Receptor Subunit Alpha, CD49e, CD49 Antigen-Like Family Member E
Anti-ITGA5 Antibody (3X608) is an antibody targeting ITGA5. Anti-ITGA5 Antibody (3X608) can be used in ELISA, IHC.
Anti-ITGA5 Antibody (3X608)
Anti-ITGA5 Antibody (3X608)
😃Good
Catalog No. TMAH-00643Alias VLA-5, ITGA5, Integrin α-F, Integrin α-5, Integrin Alpha-F, Integrin Alpha-5, FNRA, Fibronectin Receptor Subunit α, Fibronectin Receptor Subunit Alpha, CD49e, CD49 Antigen-Like Family Member E
Anti-ITGA5 Antibody (3X608) is an antibody targeting ITGA5. Anti-ITGA5 Antibody (3X608) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | 196 € | 7-10 days | |
| 100 μL | 331 € | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-ITGA5 Antibody (3X608) is an antibody targeting ITGA5. Anti-ITGA5 Antibody (3X608) can be used in ELISA, IHC. |
| Alias | VLA-5, ITGA5, Integrin α-F, Integrin α-5, Integrin Alpha-F, Integrin Alpha-5, FNRA, Fibronectin Receptor Subunit α, Fibronectin Receptor Subunit Alpha, CD49e, CD49 Antigen-Like Family Member E |
| Ig Type | hIgG1 |
| Clone | 3X608 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00643 diluted at 1:50 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human ITGA5 Protein |
| Antigen Species | Human |
| Gene ID | 3678 |
| Uniprot ID | |
| Biology Area | Signal transduction, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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