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TargetMol | Compound Library

Histamine & Melatonin Receptor-Targeted Compound Library

Catalog No. L3300

Histamine, an important bioactive molecule, is derived from the decarboxylation of the amino acid histidine. Most histamine in the body is generated in granules in mast cells and in skin, lung and gastrointestinal tract, playing a pivotal role in allergic and inflammatory reactions. Histamine acts as a neurotransmitter within the central nervous system. The histaminergic neurons that secrete histamine are localized in small regions of the hypothalamus, but those neurons send axons widely throughout the brain. Histamine appears to modulate a number of important processes in the brain, including wakefulness, cognitive ability and food consumption. Currently four histamine receptors (H1R-H4R) have been cloned and identified, all of which are G protein-coupled receptors. These different receptors are expressed on different cell types and work through different intracellular signaling mechanisms. Post mortem studies have revealed alterations in histaminergic system in neurological and psychiatric diseases. Melatonin is a hormone, produced by the pineal gland, a tiny endocrine gland situated at the center of the brain. Melatonin presents several ways of action in the regulation of seasonal reproduction, body weight and energy balance, antiaging, and promoting sleep.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L3300

Histamine & Melatonin Receptor-Targeted Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 153 compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS) for new drugs;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Histamine Receptor
5-HT Receptor
Dopamine Receptor
Adrenergic Receptor
AChR
Norepinephrine
Apoptosis
Autophagy
Melatonin Receptor
MT Receptor
Antibacterial
Endogenous Metabolite
Parasite
Calcium Channel
CaMK
Sodium Channel
Histone Methyltransferase
P450
Potassium Channel
HCV Protease
Antifungal
Mitophagy
Serotonin Transporter
iGluR
PDE
Opioid Receptor
Trk receptor
Sigma receptor
NOS
ROR
p38 MAPK
Estrogen/progestogen Receptor
Na+/Ca2+ Exchanger
Glutathione Peroxidase
HBV
Antifolate
VEGFR
Caspase
ERK
PAFR
Drug Metabolite
NMDAR
Reactive Oxygen Species
IL Receptor
cAMP
DNA
Interleukin
TGF-beta/Smad
AChE
P-gp
SARS-CoV
Influenza Virus
GPR
NF-κB
Phospholipase
MEK
Platelet aggregation
FAK
NO Synthase
HER

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