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Anti-SIGLEC8 Polyclonal Antibody 2

Catalog No. TMAB-12795 Copy Product Info
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Anti-SIGLEC8 Polyclonal Antibody 2 is a Rabbit antibody targeting SIGLEC8. Anti-SIGLEC8 Polyclonal Antibody 2 can be used in WB.

Anti-SIGLEC8 Polyclonal Antibody 2

Copy Product Info
🥰Excellent
Catalog No. TMAB-12795

Anti-SIGLEC8 Polyclonal Antibody 2 is a Rabbit antibody targeting SIGLEC8. Anti-SIGLEC8 Polyclonal Antibody 2 can be used in WB.

Anti-SIGLEC8 Polyclonal Antibody 2
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2217-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5277-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-SIGLEC8 Polyclonal Antibody 2 is a Rabbit antibody targeting SIGLEC8. Anti-SIGLEC8 Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
Reactivity
Mouse (predicted:Human)
Verified Activity
1. Sample:
Bone marrow (Mouse) Lysate at 40 μg
Spleen (Mouse) Lysate at 40 μg
Primary: Anti-CD329‘SIGLEC8 (TMAB-12795) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 50 kD
2. Sample: Cerebrum (Mouse) Lysate at 40 μg
Primary: Anti-CD329’SIGLEC8 (TMAB-12795) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 50 kD
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationMembrane; Single-pass type I membrane protein.
Tissue SpecificityExpressed specifically on eosinophils.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundSialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human SIGLEC8
Antigen Species
Human
Gene Name
SIGLEC8
Gene ID
27181
Protein Name
Sialic acid-binding Ig-like lectin 8
Uniprot ID
Q9NYZ4
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Chemical Properties
Molecular WeightTheoretical: 50 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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