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FGF-8b Protein, Human, Recombinant

Catalog No. TMPY-06986
Synonyms: NEWENTRY, fibroblast growth factor 8 (androgen-induced), FGF-8, KAL6, AIGF, HH6, HBGF-8

In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.

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FGF-8b Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
50 μg In stock $ 297.00
100 μg 5 days $ 506.00
200 μg 5 days $ 860.00
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Biological Description
Technical Params
Product Properties
Biological Information Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.4-1.6 μg/mL.
Description In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.
Species Human
Expression System E. coli
Tag Tag Free
Accession Number P55075-3
Synonyms NEWENTRY, fibroblast growth factor 8 (androgen-induced), FGF-8, KAL6, AIGF, HH6, HBGF-8
Construction The Human FGF8b (P55075-3) (Gln23-Arg215) was expressed with an initial Met.
Protein Purity > 95 % as determined by SDS-PAGE.
Molecular Weight The recombinant human FGF8b consists 194 amino acids and predicts a molecular mass of 22.5 kDa.
Endotoxin Please contact us for more information.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. . Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.

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Keywords

FGF-8b Protein, Human, Recombinant fibroblast growth factor 8 HH-6 NEWENTRY fibroblast growth factor 8 (androgen-induced) HBGF 8 FGF-8 KAL6 FGF 8 AIGF KAL 6 HH6 androgen-induced HBGF-8 KAL-6 HBGF8 FGF8 HH 6 recombinant recombinant-proteins proteins protein

 

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