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FGF-8b Protein, Human, Recombinant

Catalog No. TMPY-06986
Synonyms: NEWENTRY, fibroblast growth factor 8 (androgen-induced), FGF-8, KAL6, AIGF, HH6, HBGF-8

In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
FGF-8b Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
50 μg In stock $ 297.00
100 μg 5 days $ 506.00
200 μg 5 days $ 860.00
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Biological Description
Technical Params
Product Properties
Biological Information Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.4-1.6 μg/mL.
Description In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.
Species Human
Expression System E. coli
Tag Tag Free
Accession Number P55075-3
Synonyms NEWENTRY, fibroblast growth factor 8 (androgen-induced), FGF-8, KAL6, AIGF, HH6, HBGF-8
Construction A DNA sequence encoding the human FGF8b (P55075-3) (Gln23-Arg215) was expressed with an initial Met.
Protein Purity > 95 % as determined by SDS-PAGE.
Molecular Weight The recombinant human FGF8b consists 194 amino acids and predicts a molecular mass of 22.5 kDa.
Endotoxin Please contact us for more information.
Formulation Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Reconstitution A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.

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Keywords

FGF-8b Protein, Human, Recombinant fibroblast growth factor 8 HH-6 NEWENTRY fibroblast growth factor 8 (androgen-induced) HBGF 8 FGF-8 KAL6 FGF 8 AIGF KAL 6 HH6 androgen-induced HBGF-8 KAL-6 HBGF8 FGF8 HH 6 recombinant recombinant-proteins proteins protein

 

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