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ZM241385

Name: ZM241385
Brand: TargetMol
SKU: T7021
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7021Cas No. 139180-30-6

ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.

ZM241385

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Purity: 99.69%

Catalog No. T7021Cas No. 139180-30-6

ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$71	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$233	In Stock	In Stock
100 mg	$432	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.69%

Color:White

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COA

Product Introduction

Bioactivity

Description	ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.
Targets&IC50	A2A receptor:1.4 nM (Ki)
In vitro	ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52[3]. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7?min) OGD period, and protect CA1 neuron and astrocyte from injury[4].
In vivo	ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists[1].
Cell Research	Nitric oxide (NO) production is assessed by measuring the amount of nitrite, a stable metabolic product of NO that provides an indirect measurement of NO, by using the Griess diazotization reaction. Briefly, 24 h after incubation with 1.0 µM CG21680 or 1.0 µM ZM241385 or exposure to SMF, samples of medium (150 µl) are collected from cells and mixed with 130 µl dWater and with 20 µl Griess reagent using instruction supplied by the manufacturer. After a 30 min incubation period at room temperature, the samples are evaluated spectrophotometrically at 548 nm and OD values-in comparison with a standard curve is determined in culture medium by using serial dilutions of sodium nitrite-represented total stable metabolites of NO. (Only for Reference)

Chemical Properties

Molecular Weight	337.34
Formula	C₁₆H₁₅N₇O₂
Cas No.	139180-30-6
Smiles	Nc1nc(NCCc2ccc(O)cc2)nc2nc(nn12)-c1ccco1
Relative Density.	1.59 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 1.7 mg/mL (5.04 mM), Sonication is recommended.

DMSO: 120 mg/mL (355.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9644 mL	14.8218 mL	29.6437 mL	148.2184 mL
5 mM	0.5929 mL	2.9644 mL	5.9287 mL	29.6437 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2964 mL	1.4822 mL	2.9644 mL	14.8218 mL
20 mM	0.1482 mL	0.7411 mL	1.4822 mL	7.4109 mL
50 mM	0.0593 mL	0.2964 mL	0.5929 mL	2.9644 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	1.4822 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc