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Anti-PNPLA2 Antibody (8N289)
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Catalog No. TMAH-00993
Anti-PNPLA2 Antibody (8N289) is an antibody targeting PNPLA2. Anti-PNPLA2 Antibody (8N289) can be used in ELISA,FCM.
Anti-PNPLA2 Antibody (8N289)
Anti-PNPLA2 Antibody (8N289)
😃Good
Catalog No. TMAH-00993
Anti-PNPLA2 Antibody (8N289) is an antibody targeting PNPLA2. Anti-PNPLA2 Antibody (8N289) can be used in ELISA,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PNPLA2 Antibody (8N289) is an antibody targeting PNPLA2. Anti-PNPLA2 Antibody (8N289) can be used in ELISA,FCM. |
| Ig Type | Rabbit IgG |
| Clone | 8N289 |
| Reactivity | Human |
| Verified Activity | Overlay Peak curve showing HepG2 cells stained with TMAH-00993 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | |
| Recommended Dose | FCM:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Lipid droplet. Cell membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner seg |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone. Also has acylglycerol transacylase activity. Acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade. Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human PNPLA2 |
| Antigen Species | Human |
| Gene Name | PNPLA2 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
TTS2.2TTS2TTS 2.2TTS 2Transport-secretion protein 2 (TTS2)PNPLA2PNPLA 2Pigment epithelium-derived factor receptor (PEDF-R)PEDF-RPEDFRPatatin-like phospholipase domain-containing protein 2iPLA2-ζiPLA2ζiPLA2-zetaiPLA2zetaDesnutrinCalcium-independent phospholipase A2-ζ (iPLA2-ζ)Calcium-independent phospholipase A2-zeta (iPLA2-zeta)ATGLAdipose triglyceride lipase
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