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Methylbenactyzium Bromide

Name: Methylbenactyzium Bromide
Brand: TargetMol
SKU: T6744
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6744Cas No. 3166-62-9

Alias Semulgin, Paragone, Noinarin, Methylbenactyzine Bromide, Gastrimade

Methylbenactyzium Bromide (Semulgin) is an anticonvulsant that is the active metabolite of trimethadione.

Methylbenactyzium Bromide

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Purity: 99.29%

Catalog No. T6744Alias Semulgin, Paragone, Noinarin, Methylbenactyzine Bromide, GastrimadeCas No. 3166-62-9

Methylbenactyzium Bromide (Semulgin) is an anticonvulsant that is the active metabolite of trimethadione.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$40	In Stock	In Stock
500 mg	$106	In Stock	In Stock
1 g	$155	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.29%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Methylbenactyzium Bromide (Semulgin) is an anticonvulsant that is the active metabolite of trimethadione.
Targets&IC50	mAChR:
In vitro	TW-37 targets the BH3-binding groove in Bcl-2 where proapoptotic Bcl-2 proteins bind, and shows higher affinity and selectivity for Bcl-2 and Mcl-1 over Bcl-xL with Ki values of 0.29 μM, 0.26 μM and 1.11 μM, respectively. [1] In vitro, TW-37 shows significant anti-proliferative and pro-apoptotic effect in a de novo chemo-resistant WSU-DLCL2 lymphoma cell line and primary cells obtained from a lymphoma patient without effects on normal peripheral blood lymphocytes. [1] TW-37 exhibits the inhibitory effect on both cell growth and cell death in endothelial cell with IC50 of approximately 1.8 μM without effect on the fibroblasts exposed to the same concentration range as the endothelial cells. In addition, TW37 also shows the anti-proliferation effects in MCF-7, LNCaP, and SLK tumor cell lines with the same or lower concentration range than those required to inhibit endothelial cell growth. [2]
Synonyms	Semulgin, Paragone, Noinarin, Methylbenactyzine Bromide, Gastrimade

Chemical Properties

Molecular Weight	422.36
Formula	C₂₁H₂₈BrNO₃
Cas No.	3166-62-9
Smiles	O=C(OCC[N+](CC)(CC)C)C(C1=CC=CC=C1)(O)C2=CC=CC=C2.[Br-]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (118.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3676 mL	11.8382 mL	23.6765 mL	118.3824 mL
5 mM	0.4735 mL	2.3676 mL	4.7353 mL	23.6765 mL
10 mM	0.2368 mL	1.1838 mL	2.3676 mL	11.8382 mL
20 mM	0.1184 mL	0.5919 mL	1.1838 mL	5.9191 mL
50 mM	0.0474 mL	0.2368 mL	0.4735 mL	2.3676 mL
100 mM	0.0237 mL	0.1184 mL	0.2368 mL	1.1838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc