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ONO-8590580

Name: ONO-8590580
Brand: TargetMol
SKU: TQ0040
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0040Cas No. 1802661-73-9

Alias CS-2894

ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.

ONO-8590580

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Purity: 99.43%

Catalog No. TQ0040Alias CS-2894Cas No. 1802661-73-9

ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	In Stock	In Stock
5 mg	$128	In Stock	In Stock
10 mg	$178	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$592	In Stock	In Stock
100 mg	$845	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$143	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.43%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.
In vivo	The study investigates the effects of ONO-8590580 on MK-801/scopolamine-induced cognitive deficits using the 8-arm radial maze test, with doses of MK-801 and scopolamine at 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.), respectively. ONO-8590580 (20 mg/kg, p.o.) significantly reduces errors and total latency compared to the control. Unlike donepezil, ONO-8590580 significantly decreases the number of errors, suggesting it may be more effective for treating AD patients. The data indicate that ONO-8590580 is a novel GABAA α5 NAM that enhances hippocampal memory function without causing anxiogenic or proconvulsant effects.
Synonyms	CS-2894

Chemical Properties

Molecular Weight	376.43
Formula	C₂₁H₂₁FN₆
Cas No.	1802661-73-9
Smiles	Cc1c(F)c(Nc2ccc(cn2)-c2cn(C)cn2)cc2n(CC3CC3)cnc12
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (159.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6565 mL	13.2827 mL	26.5654 mL	132.8268 mL
5 mM	0.5313 mL	2.6565 mL	5.3131 mL	26.5654 mL
10 mM	0.2657 mL	1.3283 mL	2.6565 mL	13.2827 mL
20 mM	0.1328 mL	0.6641 mL	1.3283 mL	6.6413 mL
50 mM	0.0531 mL	0.2657 mL	0.5313 mL	2.6565 mL
100 mM	0.0266 mL	0.1328 mL	0.2657 mL	1.3283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc