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Anti-AXL Antibody-PE (3M593)
🥰Excellent
Catalog No. TMAY-00555P
Anti-AXL Antibody-PE (3M593) is a PE-conjugated Rabbit antibody targeting AXL. Anti-AXL Antibody-PE (3M593) can be used in FCM.
Anti-AXL Antibody-PE (3M593)
Anti-AXL Antibody-PE (3M593)
🥰Excellent
Catalog No. TMAY-00555P
Anti-AXL Antibody-PE (3M593) is a PE-conjugated Rabbit antibody targeting AXL. Anti-AXL Antibody-PE (3M593) can be used in FCM.
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Product Introduction
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Chemical Properties
| Description | Anti-AXL Antibody-PE (3M593) is a PE-conjugated Rabbit antibody targeting AXL. Anti-AXL Antibody-PE (3M593) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 3M593 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human AXL expression on DU145 cells. Cells were stained with PE-conjugated anti-Human AXL. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 2 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human AXL (rh AXL; TMPY-01601; AAB20305.1; Met1-Pro449) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human AXL Protein (TMPY-01601) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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