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Anti-CD25/IL2R alpha Antibody (3D865)
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Catalog No. TMAY-03907
Alias interleukin 2 receptor, α, interleukin 2 receptor, alpha, CD25/IL2R α
Anti-CD25/IL2R alpha Antibody (3D865) is a Mouse antibody targeting CD25/IL2R alpha. Anti-CD25/IL2R alpha Antibody (3D865) can be used in ELISA.
Anti-CD25/IL2R alpha Antibody (3D865)
Anti-CD25/IL2R alpha Antibody (3D865)
😃Good
Catalog No. TMAY-03907Alias interleukin 2 receptor, α, interleukin 2 receptor, alpha, CD25/IL2R α
Anti-CD25/IL2R alpha Antibody (3D865) is a Mouse antibody targeting CD25/IL2R alpha. Anti-CD25/IL2R alpha Antibody (3D865) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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| Description | Anti-CD25/IL2R alpha Antibody (3D865) is a Mouse antibody targeting CD25/IL2R alpha. Anti-CD25/IL2R alpha Antibody (3D865) can be used in ELISA. |
| Alias | interleukin 2 receptor, α, interleukin 2 receptor, alpha, CD25/IL2R α |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 3D865 |
| Reactivity | Cynomolgus |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Cynomolgus CD25/IL-2R alpha ( TMPY-03644; H6WS54; Met1-Arg213). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated T cells and regulatory T cells and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high-affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covalently with the IL2 receptor beta and gamma chain, and subsequently initiates the intracellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling. The IL2RA (CD25) gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes. Recently, a piece of strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type 1 diabetes (T1D). Cancer growth and development are associated with the stimulation of the innate immune system, including enhanced interleukin 2 receptor (IL-2R) expression in immune cells and its shedding into the circulation in a soluble form of SIL-2Ralpha. In most hematological malignancies, including different types of leukemias and lymphomas, SIL-2Ralpha is released directly from the surface of neoplastic cells thus reflecting the tumor bulk, turnover, and activity. Several studies have proved that not only lymphoid cancer cells but also some non-lymphoid cancer cells, express IL-2R on their surface. They include malignant melanoma and carcinomas of the kidney, head and neck, esophagus, and lung. Thus, sIL-2Ralpha is elevated in most proliferative disturbances of the hematopoietic system and many solid tumors.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Cynomolgus CD25/IL-2R alpha Protein (TMPY-03644) |
| Antigen Species | Cynomolgus |
| Biology Area | Neuroinflammation, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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