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(-)-p-Bromotetramisole Oxalate

🥰Excellent
Catalog No. T6353Cas No. 62284-79-1
Alias L-p-Bromotetramisole oxalate, 6-Bromolevamisole oxalate, (-)-p-Bromolevamisole oxalate

(-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) is a potent and non-specific inhibitor of alkaline phosphatase.

(-)-p-Bromotetramisole Oxalate

(-)-p-Bromotetramisole Oxalate

🥰Excellent
Purity: 99.88%
Catalog No. T6353Alias L-p-Bromotetramisole oxalate, 6-Bromolevamisole oxalate, (-)-p-Bromolevamisole oxalateCas No. 62284-79-1
(-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) is a potent and non-specific inhibitor of alkaline phosphatase.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$43In StockIn Stock
50 mg$57In StockIn Stock
100 mg$102In StockIn Stock
500 mg$248-In Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.88%
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Product Introduction

Bioactivity
Description
(-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) is a potent and non-specific inhibitor of alkaline phosphatase.
In vitro
Aurora A Inhibitor I is a 2,4-dianilinopyrimidine that selectively and potently inhibits Aurora A. Aurora A Inhibitor I effectively inhibits the proliferation of HCT116 and HT29 cells, with IC50 of 190 nM and 2.9 μM, respectively. The Aurora A selectivity of Aurora A Inhibitor I against Aurora B depends on a single amino acid (Thr217) of Aurora A. [1] In KCL-22 cells, Aurora A Inhibitor I (1-5 μM) increases G2/M cell fraction, induces histone H3 serine 10 phosphorylation, and suppresses mitotic Aurora A autophosphorylation on Thr288. Aurora A Inhibitor I (0.5-5 μM) also suppresses cell proliferation in KCL-22 cells, as well as BCR-ABL-negative leukemia cell lines KG-1 and HL-60. Aurora A Inhibitor I effectively induces apoptosis in KCL-22 cells at 5 μM. [2] In a recent study, Aurora A Inhibitor I is also found to inhibit cell growth of HCT116, HT29, and HeLa cells, with IC50 of 377.6 nM, 5.6 μM, and 416 nM. [3]
SynonymsL-p-Bromotetramisole oxalate, 6-Bromolevamisole oxalate, (-)-p-Bromolevamisole oxalate
Chemical Properties
Molecular Weight373.22
FormulaC13H13BrN2O4S
Cas No.62284-79-1
SmilesOC(=O)C(O)=O.Brc1ccc(cc1)[C@H]1CN2CCSC2=N1
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 28 mg/mL (75.02 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 60 mg/mL (160.76 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.36 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.6794 mL13.3969 mL26.7938 mL133.9692 mL
5 mM0.5359 mL2.6794 mL5.3588 mL26.7938 mL
10 mM0.2679 mL1.3397 mL2.6794 mL13.3969 mL
20 mM0.1340 mL0.6698 mL1.3397 mL6.6985 mL
50 mM0.0536 mL0.2679 mL0.5359 mL2.6794 mL
DMSO
1mg5mg10mg50mg
100 mM0.0268 mL0.1340 mL0.2679 mL1.3397 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Phosphatasep-Bromotetramisole Oxalatep-Bromolevamisole OxalateL-p-Bromotetramisole OxalateInhibitorinhibitalkaline phosphatase6-Bromolevamisole Oxalate6-Bromolevamisole()pBromotetramisole Oxalate( ) p Bromotetramisole Oxalate
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