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H-D-Trp-OH

Name: H-D-Trp-OH
Brand: TargetMol
SKU: T4806
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4806Cas No. 153-94-6

Alias D-Tryptophan

H-D-Trp-OH (D-Tryptophan) is one of the 20 standard amino acids. The D-stereoisomer is occasionally found in naturally produced peptides (e.g. contryphan, the marine venom peptide).

H-D-Trp-OH

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Purity: 99.79%

Catalog No. T4806Alias D-TryptophanCas No. 153-94-6

H-D-Trp-OH (D-Tryptophan) is one of the 20 standard amino acids. The D-stereoisomer is occasionally found in naturally produced peptides (e.g. contryphan, the marine venom peptide).

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$31	-	In Stock
10 g	$48	-	In Stock
25 g	$89	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.79%

Color:White

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COA LCMS HNMR

Product Introduction

H-D-Trp-OH AI Summary

H-D-Trp-OH exhibits bioactivity primarily as an activator of various carbonic anhydrase (CA) enzymes from multiple species. It demonstrates significant activation of human recombinant CA isoforms, including CA1 (KA = 41.0 µM), CA2 (KA = 12.0 µM), CA3 (KA = 19.0 µM), and CA6 (KA = 39.0 µM). The compound also shows potent activation of mouse recombinant CA13 (KA = 0.81 µM) and other CA isoforms such as CA4, CA7, CA9, CA12, CA14, and CA15 with varied affinities. Furthermore, H-D-Trp-OH activates non-human CA enzymes, including those from Methanothermobacter thermautotrophicus, Stylophora pistillata, and Sulfurihydrogenibium species, often exhibiting stronger activation (KA values as low as 0.002 µM). Outside of carbonic anhydrase activity, H-D-Trp-OH has shown inhibitory effects on other enzymes and biological processes, including stromelysin catalytic domain (IC50 > 500,000 nM) and human dihydrofolate reductase (Ki = 880,000 nM). Additionally, it inhibits LAT1 (IC50 = 380,000 nM) and HDAC6, albeit with lower potencies. Overall, H-D-Trp-OH holds promise as a modulator of CA enzymes, potentially applicable to various physiological and medical contexts that involve carbonic anhydrase activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	H-D-Trp-OH (D-Tryptophan) is one of the 20 standard amino acids. The D-stereoisomer is occasionally found in naturally produced peptides (e.g. contryphan, the marine venom peptide).
Synonyms	D-Tryptophan

Chemical Properties

Molecular Weight	204.23
Formula	C₁₁H₁₂N₂O₂
Cas No.	153-94-6
Smiles	C([C@H](C(O)=O)N)C=1C=2C(NC1)=CC=CC2
Relative Density.	1.362 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 39.2 mM, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8964 mL	24.4822 mL	48.9644 mL	244.8220 mL
5 mM	0.9793 mL	4.8964 mL	9.7929 mL	48.9644 mL
10 mM	0.4896 mL	2.4482 mL	4.8964 mL	24.4822 mL
20 mM	0.2448 mL	1.2241 mL	2.4482 mL	12.2411 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc